Clonal expansion of artemisinin-resistant <em>Plasmodium falciparum</em> in Uganda is associated with substandard treatment practices (Publications)
the frame of the Community Access to Rectal Artesunate for Malaria project, blood samples were collected from children with signs of severe malaria before and after RAS implementation. K13 polymorphisms were [...] a driver of this recent emergence. Rectal artesunate (RAS) as pre-referral treatment for severe malaria in children was implemented in 2019 in Northern Uganda. The objective of this study was to determine
Evaluation of anopheline diversity and abundance across outdoor collection schemes utilizing cdc light traps in Nchelenge District, Zambia (Publications)
In the global fight against malaria, standard vector control methods such as indoor residual spraying (IRS) and insecticide-treated nets (ITNs) are intended to protect inside residential structures and [...] may be exposed to outdoors. Nchelenge District in northern Zambia experiences persistently high malaria transmission even with ITNs and IRS in place. However, very few studies have examined outdoor vector [...] including a number of infectious An. funestus, may partially explain the...
High proportions of asymptomatic and submicroscopic <em>Plasmodium vivax </em>infections in a peri-urban area of low transmission in the Brazilian... (Publications)
regional elimination, it is important to investigate the role of this asymptomatic reservoir in malaria transmission in peri-urban areas. This study aimed to estimate the prevalence of Plasmodium spp. [...] conducted including all inhabitants in a peri-urban area of Manaus, western Amazonas State, Brazil. Malaria parasites were detected by light microscopy (LM) and qPCR. Sexual stages of Plasmodium spp. were [...] carried gametocytes and presented low asexual parasitemia. This reservoir actively...
Further development of simulations of Plasmodium falciparum interventions and their integration with the needs of stakeholders (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/further-development-of-simulations-of-plasmodium-falciparum-interventions-and-their-integration-with-the-needs-of-stakeholders
platform for comparing, fitting, and evaluating different individual-based stochastic simulations of malaria epidemiology. Aims In the next phase of the project, we propose to exploit the functionality of this [...] potential clients, and develop capacity to anticipate and react promptly to requests from the R & D and malaria intervention communities.
Imaging of <em>Plasmodium</em> liver stages to drive next-generation antimalarial drug discovery (Publications)
Most malaria drug development focuses on parasite stages detected in red blood cells, even though to achieve eradication, next-generation drugs active against both erythrocytic and exo-erythrocytic forms [...] imidazolopiperazine confers complete causal prophylactic protection (15 mg/kg) in rodent models of malaria and shows potent in vivo blood-stage therapeutic activity. The open source chemical tools resulting
The epidemiology of multiple <em>Plasmodium falciparum</em> infections. 7. Dynamics of multiple <em>Plasmodium falciparum </em>infections in infants... (Publications)
The force of infection and recovery rate for malaria in infants in a highly endemic area of Tanzania were analysed using polymerase chain reaction-restriction fragment length polymorphism genotyping of [...] recovery rates were in children under 4 months of age. The higher susceptibility of infants to clinical malaria in comparison with older children, in areas of very high transmission, may be largely a consequence
Synthesis and pharmacological evaluation of fluorescent and photoactivatable analogues of antiplasmodial naphthylisoquinolines (Publications)
antiplasmodial activities in vitro and in vivo, even against chloroquine-resistant strains of the malaria pathogen. For the directed optimization of these activities, an investigation of the mode of action [...] their pharmacological potential as a valuable lead structure against the widespread tropical disease malaria
Discovery and characterization of ACT-451840: an antimalarial drug with a novel mechanism of action (Publications)
More than 40 % of the world's population is at risk of being infected with malaria. Most malaria cases occur in the countries of sub-Saharan Africa, Central and South America, and Asia. Resistance to standard
Systematic review of indoor residual spray efficacy and effectiveness against <em>Plasmodium falciparum</em> in Africa (Publications)
Indoor residual spraying (IRS) is an important part of malaria control. There is a growing list of insecticide classes; pyrethroids remain the principal insecticide used in bednets but recently, novel [...] of different IRS insecticides. We report that long-lasting IRS formulations substantially reduce malaria, though their benefit over cheaper, shorter-lived formulations depends on local factors including
Trisubstituted pyrimidines as efficacious and fast-acting antimalarials (Publications)
mouse model of malaria. The most promising compound (13) showed a reduction in parasitemia of 96% when dosed at 30 mg/kg orally once a day for 4 days in the P. berghei mouse model of malaria. It also demonstrated