The effect of <em>Plasmodium falciparum</em> exposure and maternal anti-circumsporozoite protein antibodies on responses to RTS,S/AS01E vaccination in... (Publications)
BACKGROUND: The RTS,S/AS01(E) malaria vaccine showed lower antibody response and protective efficacy in infants aged 6-12 weeks compared with children aged 5-17 months (for whom this vaccine is recommended) [...] antibody immunoglobulin G (IgG) responses measured by ELISA and pre-vaccination serological markers of malaria exposure by assessing the IgG levels against 1000 P falciparum antigens using partial proteome m [...] The negative effect of maternal anti-CSP IgG in infants did not appear to...
Effect of vitamin A supplementation on morbidity due to <em>Plasmodium falciparum</em> in young children in Papua New Guinea: a randomised trial (Publications)
BACKGROUND: Many individuals at risk of malaria also have micronutrient deficiencies that may hamper protective immunity. Vitamin A is central to normal immune function, and supplementation has been shown [...] morbidity of some infectious diseases. We investigated the effect of vitamin A supplementation on malaria morbidity. METHODS: This randomised double-blind placebo-controlled trial of vitamin A supplementation [...] randomly assigned high-dose vitamin A (n=239) or placebo (n=241), every 3...
Parasitological and clinical efficacy of standard treatment regimens against <em>Plasmodium falciparum</em>, <em>P. vivax</em> and <em>P.... (Publications)
quinine+sulfadoxine/pyrimethamine (Q+SP) for malaria in a rural health centre of the East Sepik Province. 179 patients presenting with symptoms and signs of malaria and with Pf (144 patients), Pv (18 patients) [...] provided support for the recent change in the policy for the standard treatment of uncomplicated malaria in PNG from AQ or CQ to the combination of AQ+SP or CQ+SP, a recommendation aimed at slowing down
Resistance of <em>Anopheles stephensi</em> to selected insecticides used for indoor residual spraying and long-lasting insecticidal nets in Ethiopia (Publications)
BACKGROUND: Malaria, transmitted by the bite of infective female Anopheles mosquitoes, remains a global public health problem. The presence of invasive Anopheles stephensi, capable of transmitting Plasmodium [...] 2016. The ecology of this mosquito species differs from that of Anopheles arabiensis, the primary malaria vector in Ethiopia. This study aimed to evaluate the efficacy of selected insecticides, which are [...] are used in indoor residual spraying (IRS) and selected long-lasting...
Long-term acceptability, durability and bio-efficacy of ZeroVector® durable lining for vector control in Papua New Guinea (Publications)
had previously been installed in 40 homes across four study sites representing a cross section of malaria transmission risk and housing style. Structured questionnaires, DL visual inspections and group [...] at 36-months post-installation, the material and fixtures proved durable and the efficacy against malaria vectors did not decrease. However, the DL material had been removed from over 50% of the original [...] suggest DL may not be an appropriate vector control method for large-scale use in...
Assessment of global reporting of adverse drug reactions for anti-malarials, including artemisinin-based combination therapy, to the WHO Programme for... (Publications)
BACKGROUND: In spite of enhanced control efforts, malaria remains a major public health problem causing close to a million deaths annually. With support from several donors, large amounts of artemisinin-based [...] covering the period 1968-2008. All countries in the programme were clustered according to their malaria control phase and income status. The number of individual case safety reports (ICSRs) of anti-malarials [...] ICSRs suspecting anti-malarials were received from 64 countries....
Effect of vitamin A supplementation on morbidity due to <em>Plasmodium falciparum</em> in young children in Papua New Guinea: a randomised trial (Publications)
BACKGROUND: Many individuals at risk of malaria also have micronutrient deficiencies that may hamper protective immunity. Vitamin A is central to normal immune function, and supplementation has been shown [...] morbidity of some infectious diseases. We investigated the effect of vitamin A supplementation on malaria morbidity. METHODS: This randomised double-blind placebo-controlled trial of vitamin A supplementation [...] randomly assigned high-dose vitamin A (n=239) or placebo (n=241), every 3...
Long-term acceptability, durability and bio-efficacy of ZeroVector® durable lining for vector control in Papua New Guinea (Publications)
had previously been installed in 40 homes across four study sites representing a cross section of malaria transmission risk and housing style. Structured questionnaires, DL visual inspections and group [...] at 36-months post-installation, the material and fixtures proved durable and the efficacy against malaria vectors did not decrease. However, the DL material had been removed from over 50% of the original [...] suggest DL may not be an appropriate vector control method for large-scale use in...
Resistance of <em>Anopheles stephensi</em> to selected insecticides used for indoor residual spraying and long-lasting insecticidal nets in Ethiopia (Publications)
BACKGROUND: Malaria, transmitted by the bite of infective female Anopheles mosquitoes, remains a global public health problem. The presence of invasive Anopheles stephensi, capable of transmitting Plasmodium [...] 2016. The ecology of this mosquito species differs from that of Anopheles arabiensis, the primary malaria vector in Ethiopia. This study aimed to evaluate the efficacy of selected insecticides, which are [...] are used in indoor residual spraying (IRS) and selected long-lasting...
Parasitological and clinical efficacy of standard treatment regimens against <em>Plasmodium falciparum</em>, <em>P. vivax</em> and <em>P.... (Publications)
quinine+sulfadoxine/pyrimethamine (Q+SP) for malaria in a rural health centre of the East Sepik Province. 179 patients presenting with symptoms and signs of malaria and with Pf (144 patients), Pv (18 patients) [...] provided support for the recent change in the policy for the standard treatment of uncomplicated malaria in PNG from AQ or CQ to the combination of AQ+SP or CQ+SP, a recommendation aimed at slowing down
