Aligning new interventions with developing country health systems: target product profiles, presentation, and clinical trial design (Publications)
anticipated use of the intervention in target countries. Examples are provided from research on malaria vaccines that are also applicable to other new public health interventions
Analogues of thiolactomycin as potential anti-malarial and anti-trypanosomal agents (Publications)
thiolactomycin (TLM) have been synthesised and evaluated for their ability to inhibit the growth of the malaria parasite, Plasmodium falciparum. Thiolactomycin is an inhibitor of Type II fatty acid synthase which
<em>Plasmodium</em> sensitivity to artemisinins: magic bullets hit elusive targets (Publications)
the genetic basis of laboratory-induced or field-observed altered susceptibility is crucial for malaria control. In this review different models of artemisinins' molecular action are briefly presented
Discovery and structure-activity relationships of pyrrolone antimalarials (Publications)
2000-fold) compared to a mammalian cell line (L6), and significant activity against a rodent model of malaria when administered intraperitoneally. Structure-activity relationship studies have indicated ways
Ensuring transmission through dynamic host environments: host-pathogen interactions in <em>Plasmodium </em>sexual development (Publications)
A renewed global commitment to malaria elimination lends urgency to understanding the biology of Plasmodium transmission stages. Recent progress toward uncovering the mechanisms underlying Plasmodium
Using observed incidence to calibrate the transmission level of a mathematical model for <em>Plasmodium vivax</em> dynamics including case management... (Publications)
model is used to calculate local reproduction numbers in Panama and identify areas of sustained malaria transmission that should be targeted by control interventions.
Aita Signorell (People)
https://www.swisstph.ch/fr/staff/profile/people/aita-signorell
circumstances in resource limited settings and designed for poverty-related diseases like tuberculosis, malaria and sleeping sickness. Dr. Signorell’s primary interest lies in the field of community-centered medicines
Quantifying the impact of interventions against <em>Plasmodium vivax</em>: a model for country-specific use (Publications)
fictitious data, by simulating and comparing the impact of various intervention combinations on malaria risk and burden, this model could be a useful tool for strategic planning, implementation and resource
Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery (Publications)
accelerate drug discovery for diseases of poverty, the Medicines for Malaria Venture (MMV) has released box sets of 400 compounds named the Malaria, Pathogen and Stasis Boxes. Here, we screened the Pathogen Box
Adherence to standard treatment guidelines among prescribers in primary healthcare facilities in the Dodoma region of Tanzania (Publications)
in 2872 cases. The nine most prevalent conditions were upper respiratory tract infections (25%), malaria (18%), diarrhoea (9.9%), pneumonia (6.1%), skin problems (5.8%), gastrointestinal diagnoses (5%) [...] of cases that did not adhere to STG was highest with patients with skin problems and lowest for malaria. Conclusion: Prescribers' general adherence to national STG in primary HCF in the public sector in