Chemoproteomics validates selective targeting of <em>Plasmodium</em> M1 alanyl aminopeptidase as an antimalarial strategy (Publications)
New antimalarial drug candidates that act via novel mechanisms are urgently needed to combat malaria drug resistance. Here, we describe the multi-omic chemical validation of Plasmodium M1 alanyl metal
Bifurcatriol, a new antiprotozoal acyclic diterpene from the brown alga <em>Bifurcaria bifurcata</em> (Publications)
donovani) and cytotoxicity against mammalian primary cells. The highest activity was exerted against the malaria parasite P. falciparum (IC50 value 0.65 mug/mL) with low cytotoxicity (IC50 value 56.6 mug/mL). To
Predictors of residual antimalarial drugs in the blood in community surveys in Tanzania (Publications)
cross-sectional survey was conducted in 2015 in three regions of Tanzania with different levels of malaria endemicity. Interviews were conducted and blood samples collected through household surveys for further
Indole and benzimidazole bichalcophenes: synthesis, DNA binding and antiparasitic activity (Publications)
their antimicrobial activity against the tropical parasites causing African sleeping sickness and malaria. The dicyanoindoles needed to synthesize the target diamidines were obtained through Stille coupling
CRISPR-Cas9-modified <em>pfmdr1</em> protects <em>Plasmodium falciparum </em>asexual blood stages and gametocytes against a class of... (Publications)
Emerging resistance to first-line antimalarial combination therapies threatens malaria treatment and the global elimination campaign. Improved therapeutic strategies are required to protect existing drugs
Host-directed therapies for infectious diseases: current status, recent progress, and future prospects (Publications)
functional disability arising from tissue damage. The continuing epidemics of tuberculosis, HIV, malaria, and influenza, and the emergence of novel zoonotic pathogens represent major clinical management
A <em>Plasmodium falciparum</em> bromodomain protein regulates invasion gene expression (Publications)
expression of invasion genes and indicate that targeting PfBDP1 could be an invaluable tool in malaria eradication
Strategies for conducting <em>Anopheles stephensi </em>surveys in non-endemic areas (Publications)
Anopheles stephensi, a malaria vector species previously only known from Asia, was first detected in Africa in Djibouti in 2012, has been subsequently collected in Ethiopia, Sudan, and Somalia, and may
New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities (Publications)
An N-acylated furazan-3-amine of a Medicines for Malaria Venture (MMV) project has shown activity against different strains of Plasmodium falciparum. Seventeen new derivatives were prepared and tested
Spirombandakamine A3 and cyclombandakamines A8 and A9, polycyclic naphthylisoquinoline dimers, with antiprotozoal activity, from a Congolese... (Publications)
potent growth-inhibitory activity against Plasmodium falciparum, the protozoal pathogen causing malaria, and moderate effects on Trypanosoma brucei rhodesiense, the parasite responsible for African sleeping