Strategies for conducting <em>Anopheles stephensi </em>surveys in non-endemic areas (Publications)
Anopheles stephensi, a malaria vector species previously only known from Asia, was first detected in Africa in Djibouti in 2012, has been subsequently collected in Ethiopia, Sudan, and Somalia, and may
New amidated 3,6-diphenylated imidazopyridazines with potent antiplasmodium activity are dual inhibitors of <em>Plasmodium... (Publications)
idazines have demonstrated impressive in vitro activity and in vivo efficacy in mouse models of malaria infection. Herein, we report the synthesis and antiplasmodium evaluation of a new series of amidated
Comparative functional survival and equivalent annual cost of 3 long-lasting insecticidal net (LLIN) products in Tanzania: a randomised trial with... (Publications)
BACKGROUND: Two billion long-lasting insecticidal nets (LLINs) have been procured for malaria control. A functional LLIN is one that is present, is in good physical condition, and remains insecticidal [...] monitor their comparative durability to ensure that the most cost-effective products are procured for malaria control.
Incidence and consequences of damage to insecticide-treated mosquito nets in Kenya (Publications)
estimated to account for 7-11% of loss in effect on vectorial capacity for Plasmodium falciparum malaria in an analysis of repeated cross-sectional surveys of LLINs in Kenya. This does not account for the [...] nets could substantially increase their lifetime and impact but the impact of LLIN programmes on malaria transmission is ultimately limited by levels of use. Longitudinal analyses of net integrity data
Socio-cultural factors explaining timely and appropriate use of health facilities for degedege in south-eastern Tanzania (Publications)
BACKGROUND: Convulsions is one of the key signs of severe malaria among children under five years of age, potentially leading to serious complications or death. Several studies of care-seeking behaviour [...] that facilities did not provide diagnosis. CONCLUSION: The findings from this sample from a highly malaria-endemic area give support to the more recent studies showing that children with convulsions are more
Socio-cultural factors explaining timely and appropriate use of health facilities for degedege in south-eastern Tanzania (Publications)
BACKGROUND: Convulsions is one of the key signs of severe malaria among children under five years of age, potentially leading to serious complications or death. Several studies of care-seeking behaviour [...] that facilities did not provide diagnosis. CONCLUSION: The findings from this sample from a highly malaria-endemic area give support to the more recent studies showing that children with convulsions are more
Incidence and consequences of damage to insecticide-treated mosquito nets in Kenya (Publications)
estimated to account for 7-11% of loss in effect on vectorial capacity for Plasmodium falciparum malaria in an analysis of repeated cross-sectional surveys of LLINs in Kenya. This does not account for the [...] nets could substantially increase their lifetime and impact but the impact of LLIN programmes on malaria transmission is ultimately limited by levels of use. Longitudinal analyses of net integrity data
The <em>Plasmodium falciparum</em> histone methyltransferase PfSET10 is dispensable for the regulation of antigenic variation and gene expression in... (Publications)
The malaria parasite Plasmodium falciparum employs antigenic variation of the virulence factor P. falciparum erythrocyte membrane protein 1 (PfEMP1) to escape adaptive immune responses during blood infection [...] for life cycle progression in the mosquito vector or during liver stage development.IMPORTANCEThe malaria parasite Plasmodium falciparum infects hundreds of millions of people every year. To survive and
Comparative functional survival and equivalent annual cost of 3 long-lasting insecticidal net (LLIN) products in Tanzania: a randomised trial with... (Publications)
BACKGROUND: Two billion long-lasting insecticidal nets (LLINs) have been procured for malaria control. A functional LLIN is one that is present, is in good physical condition, and remains insecticidal [...] monitor their comparative durability to ensure that the most cost-effective products are procured for malaria control.
<em>In vitro</em> assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of <em>Plasmodium falciparum</em> (Publications)
OBJECTIVES: Using synchronous cultures of Plasmodium falciparum malaria, the stage sensitivity of the parasite to OZ277 (RBx-11160), the first fully synthetic antimalarial peroxide that has entered Phase