Drug repurposing in the chemotherapy of infectious diseases (Publications)
attack that are divergent share common ancestry (e.g., prokaryotic targets in the apicoplast of malaria parasites), whereas those that are convergent arise from a shared lifestyle (e.g., the susceptibility
Cytochrome P450/ABC transporter inhibition simultaneously enhances ivermectin pharmacokinetics in the mammal host and pharmacodynamics in... (Publications)
drugs that kill blood-feeding arthropods, has been proposed as a complementary strategy to reduce malaria transmission. Ivermectin is one of the leading candidates given its excellent safety profile. Here
Sustaining LLIN coverage with continuous distribution: the school net programme in Tanzania (Publications)
Most malaria-endemic countries have struggled in the past decade to establish effective national-scale continuous distribution mechanisms for long-lasting insecticidal nets (LLINs). Since the implementation
Phase III study to compare intravenous with oral iron to treat iron deficiency anaemia (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/phase-iii-study-to-compare-intravenous-with-oral-iron-to-treat-iron-deficiency-anaemia
supply, different perception of medication needs and compliance as well as concomitant diseases like malaria, soil-transmitted helminths, schistosomiasis or HIV. All these factors may influence the efficacy
Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against <em>Plasmodium falciparum</em> merozoite antigens (Publications)
BACKGROUND: Malaria is a major global cause of deaths and a vaccine is urgently needed. RESULTS: We have employed the P. falciparum merozoite antigens MSP2-3D7/FC27 and AMA1, used them in ELISA, and coupled
Characterization of the small exported <em>Plasmodium falciparum</em> membrane protein SEMP1 (Publications)
Survival and virulence of the human malaria parasite Plasmodium falciparum during the blood stage of infection critically depend on extensive host cell refurbishments mediated through export of numerous
Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant <em>Plasmodium falciparum</em>... (Publications)
Plasmodium falciparum, the most deadly malaria agent, displays a wide variety of resistance mechanisms in the field. The ability of antimalarial compounds in development to overcome these must therefore
Evidence for limited activation of distinct CD4+ T cell subsets in response to the <em>Plasmodium falciparum </em>circumsporozoite protein in Papua... (Publications)
In this study, we have studied cellular and humoral responses of individuals naturally exposed to malaria in a highly endemic region of Papua New Guinea to the circumsporozoite protein of Plasmodium falciparum
Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against <em>Plasmodium falciparum</em> merozoite antigens (Publications)
BACKGROUND: Malaria is a major global cause of deaths and a vaccine is urgently needed. RESULTS: We have employed the P. falciparum merozoite antigens MSP2-3D7/FC27 and AMA1, used them in ELISA, and coupled
Characterization of the small exported <em>Plasmodium falciparum</em> membrane protein SEMP1 (Publications)
Survival and virulence of the human malaria parasite Plasmodium falciparum during the blood stage of infection critically depend on extensive host cell refurbishments mediated through export of numerous