Validation of <em>Plasmodium falciparum</em> dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity (Publications)
BACKGROUND: Malaria remains as a major global problem, being one of the infectious diseases that engender highest mortality across the world. Due to the appearance of resistance and the lack of an effective
Infectious and non-communicable health conditions among East African immigrants at arrival and post integration in Switzerland (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/infectious-and-non-communicable-health-conditions-among-east-african-immigrants-at-arrival-and-post-integration-in-switzerland
East African immigrants at arrival in Switzerland: 1. Infectious disorders: - Parasitic infections (malaria, schistosoma, strongyloides and other stool-helminths) - Viral infections (hepatitis B and C, HIV)
Thematic areas and complexity of integrated community case management (iCCM) design, implementation, and evaluation: protocol for a scoping review (Publications)
management (iCCM) is a community-based child health strategy designed to reduce deaths due to pneumonia, malaria, and diarrhea in low-income countries. Due to the integrated nature of the intervention and the diversity
Ecohealth and adaptation to climate change in water and health sectors in West (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/ecohealth-and-adaptation-to-climate-change-in-water-and-health-sectors-in-west
in West Africa and by changing ecological conditions for vectors of some water related disease (malaria, schistosomiasis). There is a paucity of data showing key vulnerabilities to and resilience strategies
2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage <em>Plasmodium</em> infections (Publications)
acid biosynthesis pathway (PfFAS-II) has recently been shown to be indispensable for liver stage malaria parasites, the inhibitory potential of the HDAs against multiple P. falciparum FAS-II (PfFAS-II)
Pre-existing partner-drug resistance to artemisinin combination therapies facilitates the emergence and spread of artemisinin resistance: a consensus... (Publications)
artemisinin resistance. Each model simulates 100 000 individuals in a particular transmission setting (malaria prevalence of 1%, 5%, 10%, or 20%) with a daily time step that updates individuals' infection status
Patient variability in the blood-stage dynamics of <em>Plasmodium falciparum </em>captured by clustering historical data (Publications)
(within-host models), and can predict the impact of control strategies that affect the blood-stage of malaria. However, the dynamics of P. falciparum blood-stage infections are highly variable between individuals
Semi-field evaluation of freestanding transfluthrin passive emanators and the BG sentinel trap as a "push-pull control strategy" against <em>Aedes... (Publications)
push-pull system. Push-pull systems have been shown to reduce house entry and outdoor biting rates of malaria vectors and so have the potential to control other outdoor biting mosquitoes such as Aedes aegypti
Systematic review of the entomological impact of insecticide-treated nets evaluated using experimental hut trials in Africa (Publications)
Africa, diminishing the efficacy of insecticide-treated nets (ITNs) – the primary tool for preventing malaria. The entomological efficacy of indoor vector control interventions can be measured in experimental
Mining Sudanese medicinal plants for antiprotozoal agents (Publications)
by either Chagas disease, African trypansomiasis or leishmaniasis, and more than 200 million by malaria. Most of the currently available drugs have drawbacks in terms of toxicity, limited oral availability