Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease (Publications)
Parkinson's disease (PD) is a neurodegenerative disorder marked by the selective degeneration of dopaminergic neurons in the nigrostriatal pathway. Several lines of evidence indicate that mitochondria
Evaluation of media and derivatization chemistry for six aldehydes in a passive sampler (Publications)
We evaluated the GMD passive sampler for its suitability to measure six aldehydes over a 7-d period in population exposure studies. The six target aldehydes were formaldehyde, acetaldehyde, acrolein,
<em>Plasmodium falciparum</em> cerebral malaria complicated by disseminated intravascular coagulation and symmetrical peripheral gangrene: case report... (Publications)
The case of a 56-year-old female tourist who survived cerebral Plasmodium falciparum malaria with disseminated intravascular coagulation and symmetrical peripheral gangrene, ultimately requiring amput
Global metabolic responses of NMRI mice to an experimental <em>Plasmodium berghei</em> infection (Publications)
We present a metabolism-driven top-down systems biology approach to characterize metabolic changes in the mouse resulting from an infection with Plasmodium berghei, using high-resolution (1)H NMR spec
Use of personal measurements for ozone exposure assessment: a pilot study (Publications)
During summer 1991, we collected indoor, outdoor, and personal ozone concentration data as well as time-activity data in State College, Pennsylvania. These concentrations were measured for 23 children
Glutathione transferase null genotype, broccoli, and lower prevalence of colorectal adenomas (Publications)
Cruciferous vegetables, especially broccoli, may prevent cancer through anticarcinogenic compounds. For example, broccoli contains isothiocyanates that induce carcinogen-detoxifying enzymes. Glutathio
Comparison of the in vitro drug sensitivity of <em>Trypanosoma brucei gambiense</em> strains from West and Central Africa isolated in the periods... (Publications)
The situation of human African trypanosomiasis remains serious with one of the main threats being the increasing number of relapses or treatment failures after melarsoprol treatment. In order to inves
The U.S. Environmental Protection Agency Particulate Matter Health Effects Research Centers Program: a midcourse report of status, progress, and plans (Publications)
In 1998 Congress mandated expanded U.S. Environmental Protection Agency (U.S. EPA) health effects research on ambient air particulate matter (PM) and a National Research Council (NRC) committee to pro