Positive charge in an antimalarial compound unlocks broad-spectrum antibacterial activity (Publications)
In this study, we synthesized a library of eNTRy-rule-compliant compounds by introducing ionizable nitrogen atoms to an antimalarial compound. These positively charged derivatives gained activity agai
The impact of insecticide decay on the rate of insecticide resistance evolution for monotherapies and mixtures (Publications)
BACKGROUND: The problem of insecticide decay following their deployment in public health applications is frequently highlighted as an issue for sustained disease control. There are additional concerns
Telephonic verbal autopsies among adults in South Africa: a feasibility and acceptability pilot study (Publications)
OBJECTIVE: This pilot study explores the feasibility and acceptability of using telephonic verbal autopsies (teleVAs) in South Africa to collect information on causes of death. DESIGN: Quantitative an
Performance of real-time polymerase chain reaction and Kato-Katz for diagnosing soil-transmitted helminth infections and evaluating treatment efficacy... (Publications)
BACKGROUND: The World Health Organization recommends the use of the microscopy-based Kato-Katz thick smear for diagnosing soil-transmitted helminth (STH) infections. Despite its simplicity and cost-ef
The 'Epidemic' of violence against junior doctors in Baghdad: reasons, impact and consequences (Publications)
Violence against heath care workers in Iraq has reached an 'epidemic' level. It affects health care providers, receivers of care and the health system as a whole. This study aims to explore the reason
<em>Wolbachia</em> bacteria in <em>Mansonella perstans</em> isolates from patients infected in different geographical areas: a pilot study from the... (Publications)
BACKGROUND: Mansonella perstans is a vector-borne filarial parasite widely endemic in sub-Saharan Africa, with sporadic cases in Latin America. Infection is often overlooked; treatment is not standard
Prevalence of hepatitis B virus infection and treatment eligibility in Lesotho, Southern Africa: a population-based cross-sectional study with... (Publications)
BACKGROUND AND AIMS: There is no data on hepatitis B virus (HBV) prevalence and treatment eligibility among the general population in Lesotho. We aimed to determine the prevalence of HBV infection in
Microbial Ecosystem Therapeutics 4 (MET4) elicits treatment-specific IgG responses associated with changes in gut microbiota in immune checkpoint... (Publications)
BACKGROUND: Gut microbiome modulation has shown promise in its potential to treat cancer in combination with immunotherapy. Mechanistically, the pathways and routes by which gut microbiota may influen
Identifying gaps in protection from malaria vector biting in rural Cambodia using an entomological assessment and human behaviour observations (Publications)
BACKGROUND: Forest-exposed populations remain the last significant, and most difficult to access, high-risk populations for malaria in Cambodia. Despite the availability of long-lasting insecticidal n
Global impact of parasitic infections and the importance of parasite control (Publications)
Parasites have a severe impact on animal and human health. Parasites like worms, ticks, mites, fleas, biting flies, mosquitoes, and pathogenic protozoa affect humans and their pets as well as their li
