Independent loss of immunogenic proteins in <em>Mycobacterium ulcerans</em> suggests immune evasion (Publications)
The highly immunogenic mycobacterial proteins ESAT-6, CFP-10, and HspX represent potential target antigens for the development of subunit vaccines and immunodiagnostic tests. Recently, the complete ge
Survived infancy but still vulnerable: spatial-temporal trends and risk factors for child mortality in the Agincourt rural sub-district, South Africa,... (Publications)
Targeting of health interventions to poor children at highest risk of mortality are promising approaches for enhancing equity. Methods have emerged to accurately quantify excess risk and identify spac
Optimized method for preparation of DNA from pathogenic and environmental mycobacteria (Publications)
Genomic studies on pathogenic and environmental mycobacteria are of growing interest for understanding of their evolution, distribution, adaptation, and host-pathogen interaction. Since most mycobacte
Lack of insertional-deletional polymorphism in a collection of <em>Mycobacterium ulcerans</em> isolates from Ghanaian Buruli ulcer patients (Publications)
Mycobacterium ulcerans causes the devastating infectious skin disease Buruli ulcer and has a monomorphic population structure. The resolution of conventional genetic fingerprinting methods is therefor
Single nucleotide polymorphisms on the road to strain differentiation in <em>Mycobacterium ulcerans</em> (Publications)
The genomic fine-typing of strains of Mycobacterium ulcerans, the causative agent of the emerging human disease Buruli ulcer, is difficult due to the clonal population structure of geographical lineag
Oma1, a novel membrane-bound metallopeptidase in mitochondria with activities overlapping with the m-AAA protease (Publications)
The integrity of the inner membrane of mitochondria is maintained by a membrane-embedded quality control system that ensures the removal of misfolded membrane proteins. Two ATP-dependent AAA proteases
