<em>In vitro</em> and<em> In vivo</em> evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness (Publications)
African sleeping sickness is a neglected tropical disease transmitted by tsetse flies. New and better drugs are still needed especially for its second stage, which is fatal if untreated. 28DAP010, a d
Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid <em>Trypanosoma brucei</em> (Publications)
A whole-organism screen of approximately 87000 compounds against Trypanosoma brucei brucei identified a number of promising compounds for medicinal chemistry optimization. One of these classes of comp
Baseline health conditions in selected communities of northern Sierra Leone as revealed by the health impact assessment of a biofuel project (Publications)
BACKGROUND: As biofuel projects may be associated with positive and negative effects on people's health and wellbeing, a health impact assessment was performed for the Addax Bioenergy Sierra Leone (AB
Risk factors for Buruli ulcer in Ghana - a case control study in the Suhum-Kraboa-Coaltar and Akuapem south districts of the eastern region (Publications)
BACKGROUND: Buruli ulcer (BU) is a skin disease caused by Mycobacterium ulcerans. Its exact mode of transmission is not known. Previous studies have identified demographic, socio-economic, health and
AAA proteases of mitochondria: quality control of membrane proteins and regulatory functions during mitochondrial biogenesis (Publications)
An ubiquitous and conserved proteolytic system regulates the stability of mitochondrial inner membrane proteins. Two AAA proteases with catalytic sites at opposite membrane surfaces form a membrane-in
Arginine and lysine transporters are essential for <em>Trypanosoma brucei</em> (Publications)
For Trypanosoma brucei arginine and lysine are essential amino acids and therefore have to be imported from the host. Heterologous expression in Saccharomyces cerevisiae mutants identified cationic am
