Lack of insertional-deletional polymorphism in a collection of <em>Mycobacterium ulcerans</em> isolates from Ghanaian Buruli ulcer patients (Publications)
Mycobacterium ulcerans causes the devastating infectious skin disease Buruli ulcer and has a monomorphic population structure. The resolution of conventional genetic fingerprinting methods is therefor
Single nucleotide polymorphisms on the road to strain differentiation in <em>Mycobacterium ulcerans</em> (Publications)
The genomic fine-typing of strains of Mycobacterium ulcerans, the causative agent of the emerging human disease Buruli ulcer, is difficult due to the clonal population structure of geographical lineag
Oma1, a novel membrane-bound metallopeptidase in mitochondria with activities overlapping with the m-AAA protease (Publications)
The integrity of the inner membrane of mitochondria is maintained by a membrane-embedded quality control system that ensures the removal of misfolded membrane proteins. Two ATP-dependent AAA proteases
Structural requirements of Tom40 for assembly into preexisting TOM complexes of mitochondria (Publications)
Tom40 is the major subunit of the translocase of the outer mitochondrial membrane (the TOM complex). To study the assembly pathway of Tom40, we have followed the integration of the protein into the TO
Differential gene repertoire in <em>Mycobacterium ulcerans</em> identifies candidate genes for patho-adaptation (Publications)
BACKGROUND: Based on large genomic sequence polymorphisms, several haplotypes belonging to two major lineages of the human pathogen Mycobacterium ulcerans could be distinguished among patient isolates
Severe morbidity due to <em>Opisthorchis viverrini</em> and <em>Schistosoma mekongi</em> infection in Lao PDR (Publications)
We assessed morbidity due to Opisthorchis viverrini and Schistosoma mekongi infections in 243 individuals in Lao PDR. Morbidity was associated with O. viverrini infection intensity. Co-infection with
<em>Opisthorchis viverrini</em>: efficacy and tegumental alterations following administration of tribendimidine in vivo and in vitro (Publications)
The tegumental changes in adult Opisthorchis viverrini induced by tribendimidine were analyzed by scanning electron microscopy (SEM). We exposed O. viverrini to tribendimidine at a concentration of 10
<em>CHI3L1 </em>polymorphisms, cord blood YKL-40 levels and later asthma development (Publications)
BACKGROUND: Single nucleotide polymorphisms (SNPs) in chitinase 3-like 1 (CHI3L1), the gene encoding YKL-40, and increased serum YKL-40 levels are associated with severe forms of asthma. It has never
