The influence of sensitisation to pollens and moulds on seasonal variations in asthma attacks (Publications)
No large study has described seasonal variation in asthma attacks in population based asthmatics in whom sensitisation to allergen has been measured.2,637 young adults with asthma living in 15 countri
A periodically-forced mathematical model for the seasonal dynamics of malaria in mosquitoes (Publications)
We describe and analyze a periodically-forced difference equation model for malaria in mosquitoes that captures the effects of seasonality and allows the mosquitoes to feed on a heterogeneous populati
An Increase in Bronchial Responsiveness is Associated with Continuing or Restarting Smoking (Publications)
Rationale: Bronchial responsiveness has been found to be associated with smoking, atopy and lower lung function in cross-sectional studies, but there is little information on determinants of change in
Novel <em>in vivo</em> active anti-malarials based on a hydroxy-ethyl-amine scaffold (Publications)
A novel series of anti-malarials, based on a hydroxy-ethyl-amine scaffold, initially identified as peptidomimetic protease inhibitors is described. Combination of the hydroxy-ethyl-amine anti-malarial
Whole-genome sequencing of rifampicin-resistant <em>Mycobacterium tuberculosis</em> strains identifies compensatory mutations in RNA polymerase genes (Publications)
Epidemics of drug-resistant bacteria emerge worldwide, even as resistant strains frequently have reduced fitness compared to their drug-susceptible counterparts. Data from model systems suggest that t
Approach to estimating participant pollutant exposures in the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air) (Publications)
Most published epidemiology studies of long-term air pollution health effects have relied on central site monitoring to investigate regional-scale differences in exposure. Few cohort studies have had
The effect of cyclin D1 (CCND1) G870A-polymorphism on breast cancer risk is modified by oxidative stress among Chinese women in Singapore (Publications)
Cyclin D1 (CCND1), an intracellular cell-cycle regulatory protein with checkpoint function, can promote cell proliferation or induce growth arrest and apoptosis depending on the cellular context. We h
