Prospective risk of morbidity in relation to multiplicity of infection with <em>Plasmodium falciparum </em>in Sao Tomé (Publications)
The prospective risk of acute morbidity was analysed in relation to multiplicity of Plasmodium falciparum infection in 491 individuals in a peri-urban community in São Tomé. In an initial cross-sectio
Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity (Publications)
A dual activity, conjugated approach has been taken to form hybrid molecules of two known antimalarial drugs, chloroquine (CQ) and the non-sedating H1 antagonist astemizole. A variety of linkers were
Hydrangenone, a new isoprenoid with an unprecedented skeleton from <em>Salvia hydrangea</em> (Publications)
Hydrangenone, a new heptacyclic isoprenoid with a 6/7/6/5/5 membered carbon ring skeleton, was isolated from the aerial parts of Salvia hydrangea. The structure was established by extensive NMR spectr
Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent <em>Schistosoma haematobium </em>infections (Publications)
Artemether is an efficacious antimalarial drug that also displays antischistosomal properties. Laboratory studies have found that artemether curtails the development of adult worms of Schistosoma japo
Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea (Publications)
BACKGROUND: B-type natriuretic peptide levels are higher in patients with congestive heart failure than in patients with dyspnea from other causes. METHODS: We conducted a prospective, randomized, con
