Airway responsiveness to methacholine and incidence of COPD: an international prospective cohort study (Publications)
BACKGROUND: It has been debated, but not yet established, whether increased airway responsiveness can predict COPD. Recognising this link may help in identifying subjects at risk. OBJECTIVE: We studie
Total synthesis and biological investigation of (-)-artemisinin: the antimalarial activity of artemisinin is not stereospecific (Publications)
Here, we describe an efficient and diversity oriented entry to both (-)-artemisinin (1) and to its natural antipode (+)-artemisinin starting from commercially and readily available S-(+)- and R-(-)-ci
Cleaning at home and at work in relation to lung function decline and airway obstruction (Publications)
RATIONALE: Cleaning tasks may imply exposure to chemical agents with potential harmful effects to the respiratory system, and increased risk of asthma and respiratory symptoms among professional clean
Using yeast synthetic lethality to inform drug combination for malaria (Publications)
Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of t
Orientia <em>tsutsugamushi</em> is highly susceptible to the RNA polymerase switch region inhibitor corallopyronin a <em>in vitro</em> and<em> in... (Publications)
Scrub typhus is a potentially lethal infection caused by the obligate intracellular bacterium Orientia tsutsugamushi Reports on the emergence of doxycycline-resistant strains highlight the urgent need
The effect of case management and vector-control interventions on space-time patterns of malaria incidence in Uganda (Publications)
BACKGROUND: Electronic reporting of routine health facility data in Uganda began with the adoption of the District Health Information Software System version 2 (DHIS2) in 2011. This has improved healt
Physical activity and dual disease burden among South African primary schoolchildren from disadvantaged neighbourhoods (Publications)
People from low- and middle-income countries still face challenges stemming from parasitic infections. Additionally, non-communicable diseases (NCDs) and their risk factors are rapidly increasing, whi
Anemia in tuberculosis cases and household controls from Tanzania: contribution of disease, coinfections, and the role of hepcidin (Publications)
BACKGROUND: Tuberculosis (TB) induces a systemic inflammatory state affecting iron homeostasis. Patients with TB often have additional comorbidities such as anemia which can result in poorer treat out
