The stem region of premembrane protein plays an important role in the virus surface protein rearrangement during dengue maturation (Publications)
Newly assembled dengue viruses (DENV) undergo maturation to become infectious particles. The maturation process involves major rearrangement of virus surface premembrane (prM) and envelope (E) protein
The 1992-1999 World Bank Schistosomiasis Research Initiative in China: outcome and perspectives (Publications)
Ongoing efforts over the last 50 years, aiming at the elimination of schistosomiasis in the People's Republic of China, have been spectaculary successful in reducing the prevalence and intensity of th
Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL) (Publications)
Anti-Leishmania in vitro and in vivo activities of various rhodacyanine derivatives have been examined. Among them, the fluorinatied variant SJL-01 (8) showed IC(50) of 0.011 microM against Leishmania
Tegumental changes in adult <em>Schistosoma mansoni</em> harboured in mice treated with praziquantel enantiomers (Publications)
Praziquantel administered to the host causes damage to the tegument of Schistosoma mansoni. In this study, the effects of racemic praziquantel (Pra) and its enantiomers, levo-praziquantel (L-Pra) and
Cynaropicrin: the first plant natural product with <em>in vivo</em> activity against <em>Trypanosoma brucei</em> (Publications)
A screen of 1800 plant and fungal extracts with subsequent HPLC-based activity profiling was done to identify new antiprotozoal leads from nature. This led to the identification of cynaropicrin (1) fr
