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1. Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin (Publications)

   Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin

   Pertinence:

   In two steps from dihydroartemisinin, a small array of 16 semisynthetic C-10 pyrrole Mannich artemisinin derivatives (7a-p) have been prepared in moderate to excellent yield. In vitro analysis against

2. Contribution of influenza immunity and virosomal-formulated synthetic peptide to cellular immune responses in a phase I subunit malaria vaccine trial (Publications)

   Contribution of influenza immunity and virosomal-formulated synthetic peptide to cellular immune responses in a phase I subunit malaria vaccine trial

   Pertinence:

   We have demonstrated recently in a phase Ia clinical trial that synthetic malaria peptides delivered by immuno-potentiating reconstituted influenza virosomes (IRIV) induced long-lived peptide-specific

3. Global goods movement and the local burden of childhood asthma in southern California (Publications)

   Global goods movement and the local burden of childhood asthma in southern California

   Pertinence:

   OBJECTIVES: As part of a community-based participatory research effort, we estimated the preventable burden of childhood asthma associated with air pollution in the southern California communities of

4. Non-Hodgkin lymphoma incidence in the Swiss HIV Cohort Study before and after highly active antiretroviral therapy (Publications)

   Non-Hodgkin lymphoma incidence in the Swiss HIV Cohort Study before and after highly active antiretroviral therapy

   Pertinence:

   OBJECTIVE: To assess the long-term effect of HAART on non-Hodgkin lymphoma (NHL) incidence in people with HIV (PHIV). DESIGN: Follow-up of the Swiss HIV Cohort Study (SHCS). METHODS: Between 1984 and

5. Differential recognition of Brugia malayi antigens by bancroftian filariasis sera (Publications)

   Differential recognition of Brugia malayi antigens by bancroftian filariasis sera

   Pertinence:

6. Interferons direct an effective innate response to Legionella pneumophila infection (Publications)

   Interferons direct an effective innate response to Legionella pneumophila infection

   Pertinence:

   Legionella pneumophila remains an important opportunistic pathogen of human macrophages. Its more limited ability to replicate in murine macrophages has been attributed to redundant innate sensor syst

7. Alcohol consumption and other lifestyle factors: avoidable sources of excess lead exposure (Publications)

   Alcohol consumption and other lifestyle factors: avoidable sources of excess lead exposure

   Pertinence:

   Lead concentration in whole blood of a representative sample of 471 subjects aged 20 to 74 years and living in Basle was determined in 1989/90 by flame atomic absorption spectrophotometry. The partici

8. Long-term outcome in elderly patients with chronic angina managed invasively versus by optimized medical therapy: four-year follow-up of the... (Publications)

   Long-term outcome in elderly patients with chronic angina managed invasively versus by optimized medical therapy: four-year follow-up of the randomized Trial of Invasive versus Medical therapy in Elderly patients (TIME)

   Pertinence:

   BACKGROUND: There are no prospective trial data on long-term outcomes in 80-year-old patients with chronic angina with regard to antiischemic therapy. METHODS AND RESULTS: To assess long-term survival

9. Diagnosing chronic fatigue syndrome (Publications)

   Diagnosing chronic fatigue syndrome

   Pertinence:

10. Weekend births (Letter) (Publications)

    Weekend births (Letter)

    Pertinence: