Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity (Publications)
The substitution of 6-fluoroquinolines was modified in ring positions 2 and 4. The new compounds were tested in vitro for their activities against a sensitive and a multidrug resistant strain of Plasm
Retrospective study on the usefulness of pulse oximetry for the identification of young children with severe illnesses and severe pneumonia in a rural... (Publications)
OBJECTIVE: This secondary analysis of data of a randomized controlled trial (RCT) retrospectively investigated the performance of pulse oximetry in identifying children with severe illnesses, with and
Insufficient sensitivity of laser desorption-time of flight mass spectrometry-based detection of hemozoin for malaria screening (Publications)
Laser desorption-time of flight (LD-TOF) mass spectrometry-based detection of hemozoin was assessed for its performance characteristics as a rapid screening test for malaria. In spite of good specific
Insights into the genetic diversity of <em>Mycobacterium tuberculosis</em> in Tanzania (Publications)
BACKGROUND: Human tuberculosis (TB) is caused by seven phylogenetic lineages of the Mycobacterium tuberculosis complex (MTBC), Lineage 1-7. Recent advances in rapid genotyping of MTBC based on single
Pathways and associated costs of care in patients with confirmed and presumptive tuberculosis in Tanzania: a cross-sectional study (Publications)
OBJECTIVE: To assess pathways and associated costs of seeking care from the onset of symptoms to diagnosis in patients with confirmed and presumptive tuberculosis (TB). DESIGN: Cross-sectional study.
Manganese exposure and working memory-related brain activity in smallholder farmworkers in Costa Rica: results from a pilot study (Publications)
Main sources of manganese (Mn) in the general population are diet and drinking water. Mn is also found in ethylene bisdithiocarbamate (EBDC) fungicides used in agriculture or emitted into the air by f
Fecal colonization with multidrug-resistant <em>E. coli</em> among healthy infants in rural Bangladesh (Publications)
Third generation cephalosporins (3GC) are one of the main choices for treatment of infections caused by multidrug-resistant (MDR) Gram-negative bacteria. Due to their overuse, an increasing trend of r
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis (Publications)
Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of global child mortality. New drugs for the treatment of malaria and cryptosporidiosis, in particular, are of hig