Recherche de *.

1. Synthesis and in vitro and in vivo evaluation of antimalarial polyamines (Publications)

   Synthesis and in vitro and in vivo evaluation of antimalarial polyamines

   Pertinence:

   We recently reported that 1,14-diphenylacetamide derivatives of spermine exhibit potent nM in vitro growth inhibition properties of Plasmodium falciparum. In an effort to expand the structure-activity

2. A pilot study characterizing real time exposures to particulate matter and carbon monoxide from cookstove related woodsmoke in rural Peru (Publications)

   A pilot study characterizing real time exposures to particulate matter and carbon monoxide from cookstove related woodsmoke in rural Peru

   Pertinence:

   Nearly half of the world's population is exposed to household air pollution (HAP) due to long hours spent in close proximity to unvented cooking fires. We aimed to use PM2.5 and CO measurements to cha

3. In response (Publications)

   In response

   Pertinence:

4. UV-triggered affinity-capture identifies interactions between the <em>Plasmodium falciparum</em> multidrug resistance protein 1 (PfMDR1) and... (Publications)

   UV-triggered affinity-capture identifies interactions between the <em>Plasmodium falciparum</em> multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells

   Pertinence:

   A representative of a new class of potent antimalarials with an unknown mode of action was recently described. To identify the molecular target of this class of antimalarials, we employed a photo-reac

5. The causative pathogen determines the inflammatory profile in cerebrospinal fluid and outcome in patients with bacterial meningitis (Publications)

   The causative pathogen determines the inflammatory profile in cerebrospinal fluid and outcome in patients with bacterial meningitis

   Pertinence:

6. Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives (Publications)

   Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives

   Pertinence:

   Sixty-two cationic benzyl phenyl ether derivatives (36 amidines and 26 prodrugs) were prepared and assayed for activities in vitro and in vivo against Trypanosoma brucei rhodesiense (STIB900), and in

7. Genomic analysis identifies targets of convergent positive selection in drug-resistant <em>Mycobacterium tuberculosis</em> (Publications)

   Genomic analysis identifies targets of convergent positive selection in drug-resistant <em>Mycobacterium tuberculosis</em>

   Pertinence:

   M. tuberculosis is evolving antibiotic resistance, threatening attempts at tuberculosis epidemic control. Mechanisms of resistance, including genetic changes favored by selection in resistant isolates

8. Concentrations of urinary 8-hydroxy-2'-deoxyguanosine and 8-isoprostane in women exposed to woodsmoke in a cookstove intervention study in San Marcos,... (Publications)

   Concentrations of urinary 8-hydroxy-2'-deoxyguanosine and 8-isoprostane in women exposed to woodsmoke in a cookstove intervention study in San Marcos, Peru

   Pertinence:

   Nearly half of the world's population is exposed to household air pollution (HAP) due to long hours spent in close proximity to unvented cooking fires. The effect of woodsmoke exposure on oxidative st

9. Antiprotozoal screening of 60 south African plants, and the identification of the antitrypanosomal germacranolides schkuhrin I and II (Publications)

   Antiprotozoal screening of 60 south African plants, and the identification of the antitrypanosomal germacranolides schkuhrin I and II

   Pertinence:

   Two hundred and seven extracts were prepared from sixty plants from South Africa and screened for in vitro activity against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and

10. Nonrandomized controlled trial of artesunate plus sulfadoxine-pyrimethamine with or without primaquine for preventing posttreatment circulation of... (Publications)

    Nonrandomized controlled trial of artesunate plus sulfadoxine-pyrimethamine with or without primaquine for preventing posttreatment circulation of <em>Plasmodium falciparum</em> gametocytes

    Pertinence:

    Artemisinin combination therapies eliminate immature Plasmodium falciparum gametocytes but not mature gametocytes, which may persist for up to 1 month posttreatment. A single dose of primaquine, which