8,8-dialkyldihydroberberines with potent antiprotozoal activity (Publications)
Semisynthetic 8,8-dialkyldihydroberberines (8,8-DDBs) were found to possess mid- to low-nanomolar potency against Plasmodium falciparum blood-stage parasites, Leishmania donovani intracellular amastig
Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children (Publications)
BACKGROUND: There is increasing evidence that environmental exposures determining childhood illnesses operate early in life. Prenatal exposure to a farming environment through the mother might also pl
Interaction between exposure to dairy farms and polymorphisms in the TLR2 gene determines susceptibility to asthma in European children' (Publications)
Background: The finding that the prevalence of asthma and allergies is less frequent in children raised on animal farms has led to the conjecture that exposure to microbial products modifies immune re
Praziquantel analogs with activity against juvenile<em> Schistosoma mansoni</em> (Publications)
Six amide and four urea derivatives of praziquantel were synthesized and tested for antischistosomal activity against juvenile and adults stages of Schistosoma mansoni in infected mice. Only one of th
Sequence and expression of MHC-DPB1 molecules of the new world monkey<em> Aotus nancymaae</em>, a primate model for <em>Plasmodium falciparum</em> 2 (Publications)
Aotus nancymaae represents an animal model for the pre-clinical evaluation of blood-stage vaccine candidates against Plasmodium falciparum and Plasmodium vivax. We present here the nucleotide sequence
Amino acid dimorphism and parasite immune evasion: cellular immune responses to a promiscuous epitope of<em> Plasmodium falciparum</em> merozoite... (Publications)
Like most other surface-exposed antigens of Plasmodium falciparum, the leading malaria vaccine candidate merozoite surface protein (MSP)-1 contains a large number of dimorphic amino acid positions. Th