Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species (Publications)
The antifolate anticancer drug methotrexate (MTX) has potent activity against Plasmodium falciparum in vitro. Experience of its use in the treatment of rheumatoid arthritis indicates that it could be
Longitudinal assessment of <em>Plasmodium falciparum v</em>ar gene transcription in naturally infected asymptomatic children in Papua New Guinea (Publications)
Sequestration and antigenic variation are essential for Plasmodium falciparum survival in vivo contributing to severe pathologic findings and, also, chronic infection. Both are conferred by P. falcipa
Association of daily physical activity volume and intensity with COPD severity (Publications)
PURPOSE: The purpose of this study was to assess whether daily walking activity is indicative of disease severity in patients with COPD. METHODS: Daily activity was measured by accelerometry in 107 CO
Dicationic near-linear biphenyl benzimidazole derivatives as DNA-targeted antiprotozoal agents (Publications)
A series of near-linear biphenyl benzimidazole diamidines 5a-h were synthesized from their respective diamidoximes (4a-h), through the bis-O-acetoxyamidoxime, followed by hydrogenation in glacial acet
Spousal violence in Bangladesh: a call for a public-health response (Publications)
Spousal violence against women is a serious public-health issue. Although there is a growing body of literature on this subject, there are still many unanswered questions regarding the prevalence of t
Analogues of thiolactomycin as potential antimalarial agents (Publications)
Analogues of the natural antibiotic thiolactomycin (TLM), an inhibitor of the condensing reactions of type II fatty acid synthase, were synthesized and evaluated for their ability to inhibit the growt