Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against <em>Trypanosoma... (Publications)
A significant improvement in the treatment of trypanosomiases has been achieved with the recent development of nifurtimox-eflornithine combination therapy (NECT). As an alternative to drug combination
Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of... (Publications)
Replacement of the pyridine core of antimalarial 3,5-diaryl-2-aminopyridines led to the identification of a novel series of pyrazine analogues with potent oral antimalarial activity. However, other ch
Balgacyclamides, antiplasmodial heterocyclic peptides from <em>Microcystis aeruguinosa</em> EAWAG 251 (Publications)
The isolation and structural characterization of three new heterocyclic and macrocyclic peptides, balgacyclamides A-C, from Microcystis aeruginosa EAWAG 251 are reported. The constitutions were determ
A molecular marker of artemisinin-resistant <em>Plasmodium falciparum</em> malaria (Publications)
Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities worldwide. To monitor the spread of artemisinin resistance, a molecul
Men benefit more from midlife leisure-time physical activity than women regarding the development of late-life disability - results from the KORA-age... (Publications)
OBJECTIVE: Encouraging physical activity is an important public health measure to reduce disability prevalence in the aged. The aims of this study were to determine the association between midlife phy
Structure and biosynthesis of xenoamicins from entomopathogenic <em>Xenorhabdus</em> (Publications)
During the search for novel natural products from entomopathogenic Xenorhabdus doucetiae DSM17909 and X. mauleonii DSM17908 novel peptides named xenoamicins were identified in addition to the already
Asthma during pregnancy and clinical outcomes in offspring: a national cohort study (Publications)
BACKGROUND AND OBJECTIVE: Maternal asthma is a common pregnancy complication, with adverse short-term effects for the offspring. The objective was to determine whether asthma during pregnancy is a ris