SESOTHO trial ("Switch Either near Suppression Or THOusand") - switch to second-line versus WHO-guided standard of care for unsuppressed patients on... (Publications)
BACKGROUND: The World Health Organization (WHO) recommends viral load (VL) measurement as the preferred monitoring strategy for HIV-infected individuals on antiretroviral therapy (ART) in resource-lim
Two-year impact of community-based health screening and parenting groups on child development in Zambia: follow-up to a cluster-randomized controlled... (Publications)
BACKGROUND: Early childhood interventions have potential to offset the negative impact of early adversity. We evaluated the impact of a community-based parenting group intervention on child developmen
Efficacy and safety of co-administered ivermectin plus albendazole for treating soil-transmitted helminths: a systematic review meta-analysis and... (Publications)
BACKGROUND: The soil-transmitted helminths (STH), Ascaris lumbricoides, Trichuris trichiura and hookworms infect 1.5 billion people worldwide and cause an estimated burden of 3.3 million disability-ad
Antiprotozoal diterpenes from <em>Perovskia abrotanoides</em> (Publications)
As part of a screening for new antiparasitic natural products from Iranian plants, n-hexane and ethyl acetate extracts from the aerial parts of Perovskia abrotanoides were found to exhibit strong inhi
Improving Tanzanian childbirth service quality (Publications)
Purpose The purpose of this paper is to describe a quality improvement (QI) intervention in primary health facilities providing childbirth care in rural Southern Tanzania. Design/methodology/approach
Using yeast synthetic lethality to inform drug combination for malaria (Publications)
Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of t
Orientia <em>tsutsugamushi</em> is highly susceptible to the RNA polymerase switch region inhibitor corallopyronin a <em>in vitro</em> and<em> in... (Publications)
Scrub typhus is a potentially lethal infection caused by the obligate intracellular bacterium Orientia tsutsugamushi Reports on the emergence of doxycycline-resistant strains highlight the urgent need
The effect of case management and vector-control interventions on space-time patterns of malaria incidence in Uganda (Publications)
BACKGROUND: Electronic reporting of routine health facility data in Uganda began with the adoption of the District Health Information Software System version 2 (DHIS2) in 2011. This has improved healt
