Dual strategy to design new agents targeting <em>Schistosoma mansoni</em>: advancing phenotypic and <em>Sm</em>CB1 inhibitors for improved efficacy (Publications)
In this study, we have identified and optimized two lead structures from an in-house screening, with promising results against the parasitic flatworm Schistosoma mansoni and its target protease S. man
Urinalysis as a noninvasive health screening procedure in Falconidae (Publications)
Clinical signs of renal disorders in animals, including raptors, are not specific. Furthermore, serum or plasma biochemical parameters change only when 70% of kidney function is lost. In this study, r
Outbreaks of infectious keratoconjunctivitis in alpine chamois and ibex in Switzerland between 2001 and 2003 (Publications)
Five outbreaks of infectious keratoconjunctivitis (IKC) affecting alpine chamois and ibex in the western and central Swiss Alps were recorded in 2001 to 2003. Mycoplasma conjunctivae was identified fr
Inhibition of <em>Leishmania donovani</em> transformation by hamster spleen homogenates and active human lymphocytes (Publications)
HAEMOFLAGELLATES are protozoan parasites responsible for many important diseases of man and domestic animals1. Leishmania donovani, the cause of visceral leishmaniasis or kala azar, is a widespread hu
The essential malaria protein <em>Pf</em>CyRPA targets glycans to invade erythrocytes (Publications)
Summary Plasmodium falciparum is a human-adapted apicomplexan parasite that causes the most dangerous form of malaria. P. falciparum cysteine-rich protective antigen (PfCyRPA) is an invasion complex p
Heterogeneities in the transmission of infectious agents: implications for the design of control programs (Publications)
From an analysis of the distributions of measures of transmission rates among hosts, we identify an empirical relationship suggesting that, typically, 20% of the host population contributes at least 8
The cost-effectiveness of permethrin impregnated bednets in preventing child mortality in Kassena-Nankana district of Northern Ghana (Publications)
Permethrin impregnated bednets are now being widely promoted as an effective means of protecting African children against malaria, but there is little evidence of their cost-effectiveness. The impact
Pyrimethamine-resistant <em>Plasmodium falciparum</em> parasites among Tanzanian children: a facility-based study using the polymerase chain reaction (Publications)
A mutation-specific polymerase chain reaction method was used to estimate the proportion of pyrimethamine-resistant parasites in 101 children reporting with malaria at the hospital in Ifakara, a town
Acceptability and use of insecticide impregnated bednets in northern Ghana (Publications)
A district-wide study was undertaken in a rural population of northern Ghana to identify factors influencing the acceptance and use of insecticide-impregnated bednets (IIBNs). A series of focus group
