Design and synthesis of a series of melamine-based nitroheterocycles with activity against trypanosomatid parasites (Publications)
The parasites that give rise to human African trypanosomiasis (HAT) are auxotrophs for various nutrients from the human host, including purines. They have specialist nucleoside transporters to import
O-alkoxyamidine prodrugs of furamidine: in vitro transport and microsomal metabolism as indicators of in vivo efficacy in a mouse model of... (Publications)
Five O-alkoxyamidine analogues of the prodrug 2,5-bis[4-methoxyamidinophenyl]furan were synthesized and evaluated against Trypanosoma brucei rhodesiense in the STIB900 mouse model by oral administrati
Prevalence and implications of multiple-strain infections (Publications)
Infections frequently contain multiple strains (genotypes) of the same pathogen, yet they are still usually treated as uniform entities. In this Review, we discuss problems with inconsistent definitio
Predictors and overestimation of recalled mobile phone use among children and adolescents (Publications)
A growing body of literature addresses possible health effects of mobile phone use in children and adolescents by relying on the study participants' retrospective reconstruction of mobile phone use. I
Intraspecific competition between co-infecting parasite strains enhances host survival in African trypanosomes (Publications)
It is becoming increasingly clear that under natural conditions parasitic infections commonly consist of co-infections with multiple conspecific strains. Multiple-strain infections lead to intraspecif
Antiprotozoal, antimycobacterial and cytotoxic potential of twenty-three British and Irish red algae (Publications)
As part of our continuing research on seaweeds, we have screened the crude extracts of 23 red marine algae collected from England and Ireland. The clinically important blood-stage life forms of Trypan
