Reinfection with <em>Schistosoma haematobium</em> following school-based chemotherapy with praziquantel in four highly endemic villages in Côte... (Publications)
We present the comparative evaluation of school-based chemotherapy with praziquantel on Schistosoma haematobium reinfection patterns, 6, 12, 18 and 24 months after systematic treatment of schoolchildr
Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late stage central nervous system African... (Publications)
We report the discovery of novel boron-containing molecules, exemplified by N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl-2-trifluoromethylbenzam ide (AN3520) and 4-Fluoro-N-(1-hydroxy-1,3-dihydr
Impact of a national HIV voluntary counselling and testing (VCT) campaign on VCT in a rural hospital in Tanzania (Publications)
Summary Objective To evaluate the impact of a national HIV voluntary counselling and testing (VCT) campaign on presentation to HIV care in a rural population in Tanzania. Methods Retrospective analysi
Structure-activity-based design of a synthetic malaria peptide eliciting sporozoite inhibitory antibodies in a virosomal formulation (Publications)
The circumsporozoite protein (CSP) of Plasmodium falciparum is a leading candidate antigen for inclusion in a malaria subunit vaccine. We describe here the design of a conformationally constrained syn
Synthesis and antiprotozoal activity of <em>N</em>-alkoxy analogues of the trypanocidal lead compound 4,4'-bis(imidazolinylamino)diphenylamine with... (Publications)
To improve the blood-brain barrier permeability of the trypanocidal lead compound 4,4'-bis(imidazolinylamino)diphenylamine (1), five N-alkoxy analogues were synthesized from bis(4-isothiocyanatophenyl
Preclinical profiling of the immunogenicity of a two-component subunit malaria vaccine candidate based on virosome technology (Publications)
Presentation of synthetic peptides on immunopotentiating reconstituted influenza virosomes is a promising technology for subunit vaccine development. An optimized virosomally delivered peptide represe
Novel diamidines with activity against <em>Babesia divergens</em> <em>in vitro</em> and <em>Babesia microti in vivo</em> (Publications)
Dicationic diamidines, such as diminazene and pentamidine, are well-studied chemotherapeutic agents with significant activity against parasitic diseases. The in vitro activities of novel diamidine com