Survey on animal bite injuries and their management to estimate human rabies deaths in N'Djamena, Chad (Publications)
OBJECTIVE: To estimate the annual human rabies incidence as a baseline prior to mass dog vaccination campaigns in N'Djaména, Chad. METHODS: Survey of animal bites, involving 50% of all healthcare prov
Enantioselective synthesis of encecaline-derived potent antimalarial agents (Publications)
The high antiplasmodial activity of racemic benzylamines rac- and rac- stimulated the synthesis of pure enantiomers. Ellman's chiral sulfinamides (S)- and (R)- were used as chiral auxiliaries. Condens
Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of... (Publications)
Replacement of the pyridine core of antimalarial 3,5-diaryl-2-aminopyridines led to the identification of a novel series of pyrazine analogues with potent oral antimalarial activity. However, other ch
Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against <em>Trypanosoma... (Publications)
A significant improvement in the treatment of trypanosomiases has been achieved with the recent development of nifurtimox-eflornithine combination therapy (NECT). As an alternative to drug combination
B-type natriuretic peptide in patients undergoing orthopaedic surgery: a prospective cohort study (Publications)
BACKGROUND AND OBJECTIVE: Postoperative cardiac complications pose a substantial risk to patients undergoing orthopaedic surgery. METHODS: B-type natriuretic peptide (BNP) was determined preoperativel
Predictive risk mapping of schistosomiasis in Brazil using Bayesian geostatistical models (Publications)
Schistosomiasis is one of the most common parasitic diseases in tropical and subtropical areas, including Brazil. A national control programme has been instigated in Brazil in the mid-1970s and proved
Priorities for research on meningococcal disease and the impact of serogroup A vaccination in the African meningitis belt (Publications)
For over 100 years, large epidemics of meningococcal meningitis have occurred every few years in areas of the African Sahel and sub-Sahel known as the African meningitis belt. Until recently, the main
Targeting <em>Plasmodium</em> PI(4)K to eliminate malaria (Publications)
Achieving the goal of malaria elimination will depend on targeting Plasmodium pathways essential across all life stages. Here we identify a lipid kinase, phosphatidylinositol-4-OH kinase (PI(4)K), as