Antigens released at schizont burst stimulate <em>Plasmodium falciparum</em>-specific CD4+ T cells from non-exposed donors: potential for... (Publications)
In an individual experiencing the first attack of malaria, symptoms of disease can occur at very low parasitemia. T cells and cytokines have been implicated in the etiology of disease symptoms, and ot
Relationship between humoral response to <em>Plasmodium falciparum</em> merozoite surface antigen-2 and malaria morbidity in a highly endemic area of... (Publications)
The prevalence and concentration of antibodies to merozoite surface antigen-2 (MSA-2) were measured in blood samples collected during a cross-sectional survey. Antibodies were measured by enzyme-linke
Assessment of the humoral and cell-mediated immunity against the <em>Plasmodium falciparum</em> vaccine candidates circumsporozoite protein and SPf66... (Publications)
To assess natural immunity against the circumsporozoite (CS) protein and the synthetic vaccine SPf66, immunologic studies were carried out in a highly endemic malarious area of Papua New Guinea. Antib
Cytotoxic T lymphocyte (CTL) low-responsiveness to the <em>Plasmodium falciparum</em> circumsporozoite protein in naturally-exposed endemic... (Publications)
Cytotoxic T lymphocytes (CTL) specific for epitope(s) within the circumsporozoite (CS) protein of malaria sporozoites have been shown to play an important role in protective immunity against malaria,
Insect-specific production of new GameXPeptides in <em>Photorhabdus luminescens</em> TTO1, widespread natural products in entomopathogenic bacteria (Publications)
Discovery of new natural products by heterologous expression reaches its limits, especially when specific building blocks are missing in the heterologous host or the production medium. Here, we descri
European Community Respiratory Health Survey II (ECRHS II) : final report of work package (WP 7) : assessment of chemical elements on PM2.5 collected... (Publications)
The follow-up of a cohort of adults from 21 European centres of the former European Community Respiratory Health Survey (ECRHS I, 1989-1992) will examine the long-term effects of exposure to ambient a
Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from <em>Mycobacterium tuberculosis</em> and <em>Plasmodium... (Publications)
A library of 40,000 compounds was screened for inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) protein from Arabidopsis thaliana using a photometric assay. A thiazolopyrimidine d
Economic aspects of sanitation in developing countries (Publications)
BACKGROUND: Improved sanitation has been shown to have great impacts on people's health and economy. However, the progress of achieving the Millennium Development Goals (MDGs) on halving the proportio
Assessment of ozone exposures in the greater metropolitan Toronto area (Publications)
An ozone (O3) exposure assessment study was conducted in Toronto, Ontario, Canada during the winter and summer of 1992. A new passive O3 sampler developed by Harvard was used to measure indoor, outdoo
