Evolution of two distinct phylogenetic lineages of the emerging human pathogen <em>Mycobacterium ulcerans</em> (Publications)
ABSTRACT: BACKGROUND: Comparative genomics has greatly improved our understanding of the evolution of pathogenic mycobacteria such as Mycobacterium tuberculosis. Here we have used data from a genome m
Optimized DNA preparation from mycobacteria (Publications)
Extraction of genomic DNA from mycobacteria requires special consideration because (i) many mycobacterial species exhibit extremely slow growth, and thus produce only small amounts of starting materia
Single nucleotide polymorphism typing of <em>Mycobacterium ulcerans</em> reveals focal transmission of Buruli ulcer in a highly endemic region of... (Publications)
Buruli ulcer (BU) is an emerging necrotizing disease of the skin and subcutaneous tissue caused by Mycobacterium ulcerans. While proximity to stagnant or slow flowing water bodies is a risk factor for
Large sequence polymorphisms unveil the phylogenetic relationship of environmental and pathogenic mycobacteria related to <em>Mycobacterium... (Publications)
Mycolactone is an immunosuppressive cytotoxin responsible for the clinical manifestation of Buruli ulcer in humans. It was believed to be confined to its etiologic agent, Mycobacterium ulcerans. Howev
Research capacity strengthening in low and middle income countries - an evaluation of the WHO/TDR career development fellowship programme (Publications)
Between August 2012 and April 2013 the Career Development Fellowship programme of the Special Programme for Research and Training in Tropical Diseases (World Health Organization) underwent an external
Independent loss of immunogenic proteins in <em>Mycobacterium ulcerans</em> suggests immune evasion (Publications)
The highly immunogenic mycobacterial proteins ESAT-6, CFP-10, and HspX represent potential target antigens for the development of subunit vaccines and immunodiagnostic tests. Recently, the complete ge
