3-Benzylmenadiones and their heteroaromatic analogues target the apicoplast of apicomplexa parasites: synthesis and bioimaging studies (Publications)
The apicoplast is an essential organelle for the viability of apicomplexan parasites Plasmodium falciparum or Toxoplasma gondii, which has been proposed as a suitable drug target for the development o
Waiting for surgery after hip fracture: health and/or economic risk? (Publications)
OBJECTIVES: Waiting for surgery is a disconcerting experience. It can have a negative impact on patients' outcomes and length of stay (LOS) as driver for treatment costs. Process-optimisation may be a
Externe Effekte des Verkehrs 2021 : Umwelt-, Unfall- und Gesundheitseffekte des Strassen-, Schienen-, Luft- und Schiffsverkehrs (Publications)
Ausganglage und Zweck Die externen Effekte des Verkehrs sind Bestandteil der vom Bundesamt für Statistik (BFS) publizierten Statistik «Kosten und Finanzierung des Verkehrs» (KFV). Diese umfassende Zus
Contrasting genomic epidemiology between sympatric <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> populations (Publications)
The malaria parasites Plasmodium falciparum and Plasmodium vivax differ in key biological processes and associated clinical effects, but consequences on population-level transmission dynamics are diff
Temperature-mortality associations by age and cause: a multi-country multi-city study (Publications)
BACKGROUND: Heterogeneity in temperature-mortality relationships across locations may partly result from differences in the demographic structure of populations and their cause-specific vulnerabilitie
Mental health of individuals at increased suicide risk after hospital discharge and initial findings on the usefulness of a suicide prevention project... (Publications)
BACKGROUND: Supporting individuals in managing their suicidality can prevent suicidal behavior. This study evaluated the suicide prevention project SERO, which was launched in Central Switzerland in 2
Targeting <em>Plasmodium falciparum</em> IspD in the methyl-d-erythritol phosphate pathway: urea-based compounds with nanomolar potency on target and... (Publications)
The methyl-d-erythritol phosphate (MEP) pathway has emerged as an interesting target in the fight against antimicrobial resistance. The pathway is essential in many human pathogens, including Plasmodi
Vulnerability to heat-related mortality and the effect of prevention measures: a time-stratified case-crossover study in Switzerland (Publications)
BACKGROUND: Swiss climate scenarios predict increases in the frequency and intensity of extreme heat episodes in the future. For the effective prevention of heat-related mortality, several aspects of
A genome-focused investigation reveals the emergence of a <em>Mycobacterium tuberculosis</em> strain related to multidrug-resistant tuberculosis in... (Publications)
A previous study in Pará, Northern Brazil, described a strain of Mycobacterium tuberculosis with a unique genotype (SIT2517/T1) associated with multidrug-resistant tuberculosis (MDR-TB). To improve ou
