Cynaropicrin targets the trypanothione redox system in <em>Trypanosoma brucei</em> (Publications)
In mice cynaropicrin (CYN) potently inhibits the proliferation of Trypanosoma brucei-the causative agent of Human African Trypanosomiasis-by a so far unknown mechanism. We hypothesized that CYNs ?,?-u
A primaquine-chloroquine hybrid with dual activity against <em>Plasmodium</em> liver and blood stages (Publications)
We present a new class of hybrid molecules consisting of the established antiplasmodial drugs primaquine and chloroquine. No drug is known to date that acts comparably against all stages of Plasmodium
Characterization of choline uptake in<em> Trypanosoma brucei</em> procyclic and bloodstream forms (Publications)
Choline is an essential nutrient for eukaryotic cells, where it is used as precursor for the synthesis of choline-containing phospholipids, such as phosphatidylcholine (PC). According to published dat
Mobile phone use and the risk of skin cancer: a nationwide cohort study in Denmark (Publications)
The International Agency for Research on Cancer has classified radiofrequency radiation as possibly carcinogenic. Previous studies have focused on intracranial tumors, although the skin receives much
Synthesis and antiprotozoal activity of dicationic 2, 6-diphenylpyrazines and aza-analogues (Publications)
Dicationic 2,6-diphenylpyrazines, aza-analogues and prodrugs were synthesized; evaluated for DNA affinity, activity against Trypanosoma brucei rhodesiense (T. b. r.) and Plasmodium falciparum (P. f.)
