Development of a Virosomal Malaria Vaccine Candidate
A promising concept of malaria vaccines are reconstituted influenza virosomes which display synthetic peptides of P. falciparum target antigenes on their surface. Recently, a new formulation incorporating two synthetic peptides has been demonstrated safety, immunogenicity and pilot efficacy in humans. However, we assume that a highly effective malaria subunit vaccine has to incorporate more than two components. Goal of this project is to develop additional peptide mimetics derived from the novel blood stage antigens CyRPA and RH5 and to evaluate their protective efficacy in an innovative P. falciparum infection mouse model.