Head of Group

Valérie D'Acremont


Kristina Keitel-Hasler

Management of Fevers

In tropical primary care facilities, fever is one of the most frequent complaint presented by patients. With the global decline in malaria transmission and emergence of viral epidemics, more attention has been recently given to non-malaria causes of febrile episodes. Health workers urgently need novel diagnostic tools and evidence-based guidelines to better manage febrile patients in an integrated way. The goal is to improve clinical outcome through targeted appropriate treatment, but also decrease unnecessary antimicrobial use to mitigate resistance. The group on Management of Fevers is working on i) understanding and quantifying etiologies of fevers, both in adults and children; ii) finding new combination of easy-to-assess clinical predictors; iii) constructing and testing the impact of new algorithms; iv) exploring how electronic mobile technologies supporting these algorithms can modify health workers behavior and acceptability regarding guidelines; v) finding new triage tools to detect patients with severe illness to decide on immediate treatment and referral; vi) assessing the impact of integrating into algorithms host biomarkers tests results; vii) finding novel host biomarkers predicting severe/mild disease, bacterial/viral disease, and clinical failure/cure; viii) connecting directly triage tools and point-of-care tests to electronic tablets in order to calculate disease probability and guide clinicians on the best decisions to take.