The burden of bacterial antimicrobial resistance in the WHO European region in 2019: a cross-country systematic analysis (Publications)
with AMR for 23 bacterial pathogens and 88 pathogen-drug combinations for the WHO European region and its countries in 2019. Our methodological approach consisted of five broad components: the number of [...] deaths in which infection had a role, the proportion of infectious deaths attributable to a given infectious syndrome, the proportion of infectious syndrome deaths attributable to a given pathogen, the percentage [...] ON: The high levels of resistance for several important bacterial...
Causes of acute undifferentiated fever and the utility of biomarkers in Chiangrai, northern Thailand (Publications)
leptospirosis, and enteric fever continue to contribute substantially to the febrile disease burden throughout Southeast Asia while malaria is declining. Recently, there has been increasing focus on biomarkers [...] study was performed to investigate the causes of acute undifferentiated fever (AUF) in adults admitted to Chiangrai Prachanukroh hospital, northern Thailand, which included an evaluation of CRP and p [...] recruited. Scrub typhus was the leading bacterial cause of AUF (45/200,...
Causes of acute undifferentiated fever and the utility of biomarkers in Chiangrai, northern Thailand (Publications)
leptospirosis, and enteric fever continue to contribute substantially to the febrile disease burden throughout Southeast Asia while malaria is declining. Recently, there has been increasing focus on biomarkers [...] study was performed to investigate the causes of acute undifferentiated fever (AUF) in adults admitted to Chiangrai Prachanukroh hospital, northern Thailand, which included an evaluation of CRP and p [...] recruited. Scrub typhus was the leading bacterial cause of AUF (45/200,...
Mapping hotspots of malaria transmission from pre-existing hydrology, geology and geomorphology data in the pre-elimination context of Zanzibar,... (Publications)
indicate hydrological potential for vector breeding sites, but this is unsuitable for karst (limestone) landscapes such as Zanzibar where water flow, especially in the dry season, is subterranean and not controlled [...] promoting the persistence of shallow water bodies).ConclusionsThis analysis provides a tractable tool for the identification of malaria hotspots which incorporates subterranean hydrology, which can be used [...] especially for tackling outdoor biting species and for eliminating...
Mapping hotspots of malaria transmission from pre-existing hydrology, geology and geomorphology data in the pre-elimination context of Zanzibar,... (Publications)
indicate hydrological potential for vector breeding sites, but this is unsuitable for karst (limestone) landscapes such as Zanzibar where water flow, especially in the dry season, is subterranean and not controlled [...] promoting the persistence of shallow water bodies).ConclusionsThis analysis provides a tractable tool for the identification of malaria hotspots which incorporates subterranean hydrology, which can be used [...] especially for tackling outdoor biting species and for eliminating...
Mortality atlas of the main causes of death in Switzerland, 2008-2012 (Publications)
c sub-groups that account for urbanisation and linguistic areas in order to assess their effects on the different sub-groups. RESULTS: We describe the spatial pattern of the major causes of death that [...] PRINCIPLES: Analysis of the spatial distribution of mortality data is important for identification of high-risk areas, which in turn might guide prevention, and modify behaviour and health resources allocation [...] certificates for the period 2008-2012. Bayesian conditional autoregressive...
Mortality atlas of the main causes of death in Switzerland, 2008-2012 (Publications)
c sub-groups that account for urbanisation and linguistic areas in order to assess their effects on the different sub-groups. RESULTS: We describe the spatial pattern of the major causes of death that [...] PRINCIPLES: Analysis of the spatial distribution of mortality data is important for identification of high-risk areas, which in turn might guide prevention, and modify behaviour and health resources allocation [...] certificates for the period 2008-2012. Bayesian conditional autoregressive...
Population pharmacokinetics of the antimalarial amodiaquine: a pooled analysis to optimize dosing (Publications)
n model, with first-order elimination leading to the formation of desethylamodiaquine, which was best described by a three-compartment disposition model. Body size and age were the main covariates affecting [...] affecting amodiaquine clearance. After adjusting for the effect of weight, clearance rates for amodiaquine and desethylamodiaquine reached 50% of adult maturation at 2.8 (95% CI: 1.5 - 3.7) and 3.9 (95% CI: [...] Amodiaquine plus artesunate is the recommended antimalarial treatment in...
Population pharmacokinetics of the antimalarial amodiaquine: a pooled analysis to optimize dosing (Publications)
n model, with first-order elimination leading to the formation of desethylamodiaquine, which was best described by a three-compartment disposition model. Body size and age were the main covariates affecting [...] affecting amodiaquine clearance. After adjusting for the effect of weight, clearance rates for amodiaquine and desethylamodiaquine reached 50% of adult maturation at 2.8 (95% CI: 1.5 - 3.7) and 3.9 (95% CI: [...] Amodiaquine plus artesunate is the recommended antimalarial treatment in...
Non-Markovian modelling highlights the importance of age structure on Covid-19 epidemiological dynamics (Publications)
assumes that the time spent in each compartment does not depend on the time already spent in it, which is at odds with the clinical data. To overcome this “memoryless” issue, a widely used solution is to increase [...] analyse and determine the major components that contributed to the Covid-19 hospital admissions. The results indicate that the observed vaccination rate alone is not enough to control the epidemic, and a global [...] a memory structure for each compartment thereby allowing us to...
