Surveillance of molecular markers of <em>Plasmodium falciparum</em> artemisinin resistance (<em>kelch</em>13 mutations) in Papua New Guinea between... (Publications)
Plasmodium falciparum resistance to artemisinin-based combination therapy (ACT) is a global threat to malaria control and elimination efforts. Mutations in the P. falciparum kelch13 gene (Pfk13) that
A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma (Publications)
The detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies in the serum of an individual indicates prior infection or vaccination. However, it provides limited i
Common haplotypes at the <em>CFH </em>locus and low-frequency variants in <em>CFHR2 </em>and <em>CFHR5 </em>associate with systemic FHR concentrations... (Publications)
Age-related macular degeneration (AMD) is the principal cause of blindness in the elderly population. A strong effect on AMD risk has been reported for genetic variants at the CFH locus, encompassing
Global estimates of the implications of COVID-19-related preprimary school closures for children's instructional access, development, learning, and... (Publications)
Observational data collected prior to the pandemic (between 2004 and 2019) were used to simulate the potential consequences of early childhood care and education (ECCE) service closures on the estimat
Discovery and structure-activity relationships of quinazolinone-2-carboxamide derivatives as novel orally efficacious antimalarials (Publications)
A phenotypic high-throughput screen allowed discovery of quinazolinone-2-carboxamide derivatives as a novel antimalarial scaffold. Structure-activity relationship studies led to identification of a po
The effect of exposure to radiofrequency fields on cancer risk in the general and working population: a protocol for a systematic review of human... (Publications)
BACKGROUND: The World Health Organization (WHO) has an ongoing project to assess potential health effects of exposure to radiofrequency electromagnetic fields (RF-EMF) in the general and working popul
Access to water and sanitation infrastructures for primary schoolchildren in the south-central part of Côte d’Ivoire (Publications)
In rural settings of Côte d’Ivoire, access to water, sanitation, and hygiene (WASH) at schools is often lacking. The purpose of this study was to assess the availability, quality, and use of WASH infr
Identification of the asymptomatic <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> gametocyte reservoir under different transmission... (Publications)
BACKGROUND: Understanding epidemiological variables affecting gametocyte carriage and density is essential to design interventions that most effectively reduce malaria human-to-mosquito transmission.
Implementation of a non-communicable disease clinic in rural Sierra Leone: early experiences and lessons learned (Publications)
This study is an evaluation of the first cohort of patients enrolled in an outpatient non-communicable disease clinic in Kono, Sierra Leone. In the first year, the clinic enrolled 916 patients. Eight
Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not... (Publications)
The Mycobacterium ulcerans exotoxin, mycolactone, is responsible for the immunosuppression and tissue necrosis that characterizes Buruli ulcer. Mycolactone inhibits SEC61-dependent co-translational tr
