Parallel synthesis and antileishmanial activity of ether-linked phospholipids (Publications)
The synthesis and antileishmanial activity of 18 edelfosine analogues are described. Compounds were obtained in parallel combining solid phase and solution phase synthesis. The most active analogue is
Inhibitors of Plasmepsin II-potential antimalarial agents (Publications)
In order to overcome the problem of drug resistance in malaria, it appears wise to concentrate drug discovery efforts toward new structural classes and new mechanisms of action. We report our results,
Use of spoligotyping and large sequence polymorphisms to study the population structure of the <em>Mycobacterium tuberculosis</em> complex in a cohort... (Publications)
Mycobacterium africanum, first described in Senegal in 1968, causes up to half of the smear-positive pulmonary tuberculosis cases in West Africa, but it has not been found in other geographical areas
Progression to active tuberculosis, but not transmission, varies by <em>Mycobacterium tuberculosis</em> lineage in The Gambia (Publications)
BACKGROUND: There is considerable variability in the outcome of Mycobacterium tuberculosis infection. We hypothesized that Mycobacterium africanum was less likely than M. tuberculosis to transmit and
<em>Mycobacterium africanum</em> elicits an attenuated T cell response to early secreted antigenic target, 6 kDa, in patients with tuberculosis and... (Publications)
BACKGROUND: Mycobacterium africanum, a member of the M. tuberculosis complex that is infrequently found outside of western Africa, is the cause of up to half of the tuberculosis cases there. METHODS:
Malaria infection prevalence and sensitivity of reactive case detection in Zanzibar (Publications)
BACKGROUND: Reactive case detection (RCD) is a commonly used strategy for malaria surveillance and response in elimination settings. Many approaches to RCD assume detectable infections are clustered w
‘The time where the British took the lead is over’: ethical aspects of writing in complex research partnerships (Publications)
Writing reflects some of the different characteristics of the language being used and of the people who are communicating. The present paper focusses on the internal written communication in internati
Antenatal care service delivery and factors affecting effective tetanus vaccine coverage in low- and middle-income countries: results of the Maternal... (Publications)
OBJECTIVES: To map the integration of existing maternal tetanus immunization programmes within antenatal care (ANC) services for pregnant women in low- and middle-income countries (LMICs) and to ident
A sister lineage of the <em>Mycobacterium tuberculosis </em>complex discovered in the African Great Lakes region (Publications)
The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have expanded from a common progenitor in Africa. However, the molecular events that accompanied
