Die Falciparum-Malaria in der Schweiz: ein Problem der Intensivmedizin? (Publications)
In the period 1972-1976, 5 of 17 patients admitted to the Cantonal Hospital, Basel, for falciparum malaria had to be treated in the intensive care unit. Two patients died. None had performed regular c
Epidemiologie und Klinik der Malaria in der Schweiz (Publications)
Plasmodium falciparum is the predominant plasmodium species in Africa south of the Sahara to a proportion of 80% and more. Two thirds of all cases of malaria in Switzerland are imported from Africa. A
Das Antiarrhythmikum Chinidin als Alternative in der Behandlung der schweren Falciparum-Malaria (Publications)
Parenteral quinine is the most effective treatment for severe falciparum malaria. It is not easily available in Switzerland and so dangerous delays treating patients may occur. The antiarrhythmic drug
Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities (Publications)
Trypanothione reductase (TR) is an essential enzyme of trypanosomatids and therefore a promising target for the development of new drugs against African sleeping sickness and Chagas' disease. Diaryl s
Methods development for epidemiologic investigations of the health effects of prolonged ozone exposure. Part I: Variability of pulmonary function... (Publications)
The acute and subacute effects of ambient concentrations of ozone on lung function have been studied extensively in a variety of settings. Such studies generally have focused on measures of function t
Methods development for epidemiologic investigations of the health effects of prolonged ozone exposure. Part II. An approach to retrospective... (Publications)
An extensive body of data supports a relation between acute exposures to ambient ozone and the occurrence of various acute respiratory symptoms and changes in measures of lung function. In contrast, r
Synthesis and antimalarial property of orally active phenoxazinium salts (Publications)
Phenoxazinium salts were found to display good antimalarial efficacy in vivo against Plasmodium berghei. Several compounds provided 100% parasitemia clearance at a dose of 20-30 mg kg-1x4 days (ip) an