ProCOC: the prostate cancer outcomes cohort study (Publications)
BACKGROUND: Despite intensive research over the last several decades on prostate cancer, many questions particularly those concerning early diagnosis and the choice of optimal treatment for each indiv
A research agenda for malaria eradication: health systems and operational research (Publications)
Health systems research and development is needed to support the global malaria eradication agenda. In this paper, we (the malERA Consultative Group on Health Systems and Operational Research) focus o
Population-based screening - the difficulty of how to do more good than harm and how to achieve it (Publications)
Screening people without symptoms of disease is an attractive idea. Screening allows early detection of disease or elevated risk of disease, and has the potential for improved treatment and reduction
Molecular surveillance of the antifolateresistant mutation I164L in imported African isolates of <em>Plasmodium falciparum</em> in Europe: sentinel... (Publications)
BACKGROUND: Malaria parasites that carry the DHFR-mutation I164L are not only highly resistant to sulfadoxine-pyrimethamine but also to the new antimalarial drug chlorproguanil-dapsone. The spread of
Nuclear factor I genomic binding associates with chromatin boundaries (Publications)
BACKGROUND: The Nuclear Factor I (NFI) family of DNA binding proteins (also called CCAAT box transcription factors or CTF) is involved in both DNA replication and gene expression regulation. Using chr
Estimating <em>Plasmodium falciparum</em> transmission rates in low-endemic settings using a combination of community prevalence and health facility... (Publications)
As some malaria control programs shift focus from disease control to transmission reduction, there is a need for transmission data to monitor progress. At lower levels of transmission, it becomes incr
Sleeping sickness in travelers - do they really sleep? (Publications)
The number of imported Human African Trypanosomiasis (HAT) cases in non-endemic countries has increased over the last years. The objective of this analysis is to describe the clinical presentation of
Accuracy of urine circulating cathodic antigen test for the diagnosis of <em>Schistosoma mansoni</em> in preschool-aged children before and after... (Publications)
BACKGROUND: The Kato-Katz technique is widely used for the diagnosis of Schistosoma mansoni, but shows low sensitivity in light-intensity infections. We assessed the accuracy of a commercially availab
Development of an in vitro drug sensitivity assay for <em>Trichuris muris</em> first-stage larvae (Publications)
ABSTRACT: BACKGROUND: Trichuriasis represents a major public health problem in the developing world and is regarded as a neglected disease. Albendazole and mebendazole, the two drugs of choice against
