Chemometric and biological validation of a capillary electrophoresis metabolomic experiment of <em>Schistosoma mansoni</em> infection in mice (Publications)
Metabonomic and metabolomic studies are increasingly utilized for biomarker identification in different fields, including biology of infection. The confluence of improved analytical platforms and the
Antiparasitic activity of marine pyridoacridone alkaloids related to the ascididemins (Publications)
A series of pyridoacridone alkaloids, including the marine alkaloid ascididemin were tested in vitro for antiparasitic activity against P. falciparum (K1, NF54), L. donovani, T. cruzi, T. b. rhodesien
Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase (Publications)
Novel quinazoline-type compounds were designed as inhibitors of the parasite specific enzyme trypanothione reductase (TR), and their biological activities were evaluated. Some of our compounds inhibit
Influence of HIV-related immunodeficiency on the risk of hepatocellular carcinoma (Publications)
OBJECTIVE: To investigate HIV-related immunodeficiency as a risk factor for hepatocellular carcinoma (HCC) among persons infected with HIV, while controlling for the effect of frequent coinfection wit
Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS) (Publications)
BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially mod
