dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors (Publications)
Pyrimidine metabolism is a major route for therapeutic intervention against malaria. Here we report inhibition and structural studies on the deoxyuridine nucleotidohydrolase from the malaria parasite
Identification of fecal input sites in spring water by selection and genotyping of multiresistant <em>Escherichia coli</em> (Publications)
The localization of fecal input sites is important for water quality management. For this purpose, we have developed a new approach based on a three-step procedure, including a preparatory phase, the
The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks <em>Plasmodium falciparum</em> transmission to Anopheles... (Publications)
The global malaria agenda has undergone a reorientation from control of clinical cases to entirely eradicating malaria. For that purpose, a key objective is blocking transmission of malaria parasites
Risk of<em> vibrio</em> transmission linked to the consumption of crustaceans in coastal towns of Côte d'Ivoire (Publications)
The purpose of this study was to assess the risk of Vibrio spp. transmission from crustaceans to humans in two coastal towns of Cote d'Ivoire. Bacteriologic analysis was performed on 322 crustacean sa
Schistosomiasis and soil-transmitted helminthiasis: common drugs for treatment and control (Publications)
Schistosomiasis is a disease caused by parasitic trematode worms (schistosomes) that currently affects 200 million people living in tropical and subtropical environments. It is a chronic disease and t
Repeated cross-sectional skin testing for bovine tuberculosis in cattle kept in a traditional husbandry system in Ethiopia (Publications)
Representative repeated cross-sectional skin testing for bovine tuberculosis (TB) was conducted over a period of three years in a total of 5377 cattle in three randomly selected woredas (districts) in
Oral artemether for prevention of <em>Schistosoma mansoni</em> infection: randomised controlled trial (Publications)
BACKGROUND: Chemotherapy with praziquantel is the current strategy of choice to control schistosomiasis. However, in view of concern about praziquantel tolerance or resistance, new drugs are needed. A