Estimation of the sequestered parasite load in severe malaria patients using both host and parasite markers (Publications)
The virulence of the malaria parasite Plasmodium falciparum is due, in part, to its ability to cytoadhere in deep vascular beds. Our inability to quantify the load of sequestered parasites hampers our
Less common parasitic infections in Southeast Asia that can produce outbreaks (Publications)
The culturally deeply rooted habit of eating raw or undercooked foodstuffs, coupled with inadequate hygiene practices and lack of separation between foodstuff and wildlife in parts of Southeast Asia h
The antiprotozoal activity of sixteen asteraceae species native to Sudan and bioactivity-guided isolation of xanthanolides from <em>Xanthium... (Publications)
IN VITRO screening of the dichloromethane extracts of 16 Asteraceae species native to Sudan for activity against major protozoan pathogens revealed that a XANTHIUM BRASILICUM Vell. [syn. X. STRUMARIUM
Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug... (Publications)
Drug resistance against dihydrofolate reductase (DHFR) inhibitors-such as pyrimethamine (PM)-has now spread to almost all regions where malaria is endemic, rendering antifolate-based malaria treatment
Efficacy of killed whole-parasite vaccines in the prevention of leishmaniasis: a meta-analysis (Publications)
Despite decades of investigation in countries on three continents, an efficacious vaccine against Leishmania infections has not been developed. Although some indication of protection was observed in s
Efficacy of the cyclooctadepsipeptide PF1022A against <em>Heligmosomoides bakeri in vitro</em> and <em>in vivo</em> (Publications)
SUMMARYThe cyclooctadepsipeptide PF1022A derived from the fungus, Mycelia sterilia, is characterized by a broad spectrum of activity against different parasitic gastrointestinal nematodes of livestock
Malaria vaccine candidate: design of a multivalent subunit alpha-helical coiled coil poly-epitope (Publications)
A new strategy for the rapid identification of new malaria antigens based on protein structural motifs was previously described. We identified and evaluated the malaria vaccine potential of fragments
Global goods movement and the local burden of childhood asthma in southern California (Publications)
OBJECTIVES: As part of a community-based participatory research effort, we estimated the preventable burden of childhood asthma associated with air pollution in the southern California communities of
