Case-control study of individuals with discrepant nucleocapsid and spike protein SARS-CoV-2 IgG results (Publications)
BACKGROUND: Laboratory-based methods for SARS-CoV-2 antibody detection vary widely in performance. However, there are limited prospectively-collected data on assay performance, and minimal clinical in
Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues (Publications)
Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B cells, which encode humoral immune memory. We evaluated pediatric and adult blood and deceased adult org
Plasma as an alternative COVID-19 diagnostic specimen in a hospitalized patient negative for SARS-CoV-2 by nasopharyngeal swab (Publications)
We present the case of an inpatient with pneumonia and repeatedly negative nasopharyngeal SARS-CoV-2 testing. In such challenging cases, alternative diagnostic options include lower respiratory tract
Adjuvanting a subunit COVID-19 vaccine to induce protective immunity (Publications)
The development of a portfolio of COVID-19 vaccines to vaccinate the global population remains an urgent public health imperative(1). Here we demonstrate the capacity of a subunit vaccine, comprising
Increased viral variants in children and young adults with impaired humoral immunity and persistent SARS-CoV-2 infection: a consecutive case series (Publications)
BACKGROUND: There is increasing concern that persistent infection of SARS-CoV-2 within immunocompromised hosts could serve as a reservoir for mutation accumulation and subsequent emergence of novel st
Evaluation of SARS-CoV-2 total antibody detection via a lateral flow nanoparticle fluorescence immunoassay (Publications)
BACKGROUND: The coronavirus disease 2019 (COVID-19) endgame may benefit from simple, accurate antibody testing to characterize seroprevalence and immunization coverage. OBJECTIVES: To evaluate the per
Decreasing incidence of conjunctival squamous cell carcinoma in people with HIV in South Africa (Publications)
BACKGROUND: The main risk factors for squamous cell carcinoma of the conjunctiva (SCCC) are immunodeficiency and exposure to ultraviolet radiation. Little is known about the SCCC epidemiology among pe
Sexual and reproductive health services use among adolescents in pastoralist settings, northeastern Ethiopia (Publications)
BACKGROUND: Adolescents have special sexual and reproductive health (ASRH) needs and are susceptible to poor health outcomes. The global burden of ill sexual health includes a significant proportion o
Socioeconomic inequalities in cervical precancer screening among women in Ethiopia, Malawi, Rwanda, Tanzania, Zambia and Zimbabwe: analysis of... (Publications)
OBJECTIVES: We examined age, residence, education and wealth inequalities and their combinations on cervical precancer screening probabilities for women. We hypothesised that inequalities in screening
