Structure-activity relationship of an ozonide carboxylic acid (OZ78) against <em>Fasciola hepatica</em> (Publications)
In this paper, we describe the SAR of ozonide carboxylic acid OZ78 (1) as the first part of our search for a trematocidal synthetic peroxide drug development candidate. We found that relatively small
Heritability of gastrointestinal nematode faecal egg counts in West African village N'Dama cattle and its relation to age (Publications)
Offspring-dam regression was used to estimate the heritability of strongyle faecal egg counts (FEC) of traditionally raised West African N'Dama cattle in the Central River Division in The Gambia. Faec
Cynaropicrin targets the trypanothione redox system in <em>Trypanosoma brucei</em> (Publications)
In mice cynaropicrin (CYN) potently inhibits the proliferation of Trypanosoma brucei-the causative agent of Human African Trypanosomiasis-by a so far unknown mechanism. We hypothesized that CYNs ?,?-u
Synthesis and antiprotozoal activity of dicationic 2, 6-diphenylpyrazines and aza-analogues (Publications)
Dicationic 2,6-diphenylpyrazines, aza-analogues and prodrugs were synthesized; evaluated for DNA affinity, activity against Trypanosoma brucei rhodesiense (T. b. r.) and Plasmodium falciparum (P. f.)
Natural product derived antiprotozoal agents: synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane... (Publications)
Various natural products with the chromane and chromene scaffold exhibit high antiprotozoal activity. The natural product encecalin (7) served as key intermediate for the synthesis of different ethers
Improved characterization of visual evoked potentials in multiple sclerosis by topographic analysis (Publications)
In multiple sclerosis (MS), the combination of visual, somatosensory and motor evoked potentials (EP) has been shown to be highly correlated with the Expanded Disability Severity Scale (EDSS) and to p
