Dept | Medical Parasitology and Infection Biology

Research on Pathogen Biology, Host-Pathogen Interaction and Immunity

In the Department of Medical Parasitology and Infection Biology, we explore the molecular and cellular mechanisms underlying pathogen survival, transmission and host-pathogen interaction. We investigate how host factors influence the response to infection and disease using various models of infection as well as clinical samples from human patients. By improving our understanding of these biological processes, we hope to contribute to the control of diseases of poverty such as malaria, tuberculosis, trypanosomiasis, dengue, Buruli ulcer and helminth infections.

Research on Pathogen Evolution and Transmission

We study how pathogens evolve to evade host immune mechanisms and develop resistance to anti-microbials, and how these phenomena influence the spread of these microbes. We apply various molecular epidemiological approaches to analyze infection and transmission dynamics, and monitor the effects of interventions such as transmission control, vaccination or drug treatment on the prevalence and population structure of these pathogens.

Development of Diagnostics, Drugs and Vaccines

We use our enhanced understanding of host-pathogen biology to develop new diagnostics, drug sensitivity assays, drugs and vaccines against these diseases. We evaluate new diagnostics, and perform both pre-clinical and clinical studies of novel treatments as well as of candidate antigens and antigen delivery systems for vaccine purposes. This work also includes the development of new animal models and controlled human infection models to assess novel interventions. These activities are carried it out in collaboration with many international institutions, including our long-term partners in endemic countries.

 

Sébastien Gagneux

Sébastien Gagneux, Associate Professor, PhD

Head of Unit, Head of Department
+41612848369
sebastien.gagneux@swisstph.ch

12.01.2018 - 09:14:19

Tackling Tuberculosis in Europe

Migration increases the risk of tuberculosis outbreaks in populations. The Swiss Tropical and Public Health Institute (Swiss TPH) contributed to the development of a pan-European... More...

29.11.2017 - 12:00:00

"Professorship of Major Strategic Importance to Swiss TPH"

November 28, 2017, the University Council of the University of Basel nominated Jennifer Keiser from the Swiss Tropical and Public Health Institute (Swiss TPH) as a new Associate... More...

Cretton S et al. A new antifungal and antiprotozoal bibenzyl derivative from Gavilea lutea. Nat Prod Res. 2018;32(6):695-701. DOI: 10.1080/14786419.2017.1338287

Wiedemar N et al. Beyond immune escape: a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei. Mol Microbiol. 2018;107(1):57-67. DOI: 10.1111/mmi.13854

Vogel G et al. Functional characterization and phenotypic monitoring of human hematopoietic stem cell expansion and differentiation of monocytes and macrophages by whole-cell mass spectrometry. Stem Cell Res. 2018;26:47-54. DOI: 10.1016/j.scr.2017.11.013

Akama T et al. Identification of a 4-fluorobenzyl L-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT). Bioorg Med Chem Lett. 2018;28(1):6-10. DOI: 10.1016/j.bmcl.2017.11.028

Lo N.C et al. Impact and cost-effectiveness of snail control to achieve disease control targets for schistosomiasis. Proc Natl Acad Sci U S A. 2018(in press). DOI: 10.1073/pnas.1708729114