Pluschke G, Warryn L. How our molecular understanding of the pathogenesis of Mycobacterium ulcerans infection can improve diagnosis of Buruli ulcer. Expert Rev Mol Diagn. 2024(1-2):1-4. DOI: 10.1080/14737159.2023.2294333

2024
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Ispasanie E, Muri L, Schmid M, Schubart A, Thorburn C, Zamurovic N, Holbro T, Kammüller M, Pluschke G. In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative complement pathway. Front Immunol. 2023;14:1180833. DOI: 10.3389/fimmu.2023.1180833

2023
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Jen F.E, Abrahams J.L, Schulz B.L, Lamelas Cabello A, Pluschke G, Jennings M.P. High-frequency changes in pilin glycosylation patterns during Neisseria meningitidis serogroup a meningitis outbreaks in the African meningitis belt. ACS Infect Dis. 2023;9:1451–1457. DOI: 10.1021/acsinfecdis.3c00149

2023
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Junghanss T, Pluschke G. Mycobacterium ulcerans disease (Buruli ulcer). In: Farrar J,Hotez P.J,Junghanss T,Kang G,Lalloo D,White N.J,Garcia P.J, eds. Manson's Tropical Diseases, 557-568. Amsterdam: Elsevier, 2023. DOI: 10.1016/B978-0-7020-7959-7.00048-8

2023
Book Section

Mäser P, Bernhard S, Brun R, Burri C, Gagneux S, Hetzel M.W, Kaiser M, Lengeler C, Pluschke G, Reus E, Rottmann M, Utzinger J, Warryn L, Wittlin S, Keiser J. Key contributions by the Swiss Tropical and Public Health Institute towards new and better drugs for tropical diseases. Chimia (Aarau). 2023;77(9):593-606. DOI: 10.2533/chimia.2023.593

2023
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Tamborrini M, Schäfer A, Hauser J, Zou L, Paris D.H, Pluschke G. The malaria blood stage antigen PfCyRPA formulated with the TLR-4 agonist adjuvant GLA-SE elicits parasite growth inhibitory antibodies in experimental animals. Malar J. 2023;22:210. DOI: 10.1186/s12936-023-04638-8

2023
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Warryn L, Pluschke G. Repurposing of tuberculosis drug candidates for the treatment of Mycobacterium ulcerans disease. Chimia (Aarau). 2023;77(9):577-581. DOI: 10.2533/chimia.2023.577

2023
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Day C.J, Poole J, Pluschke G, Jennings M.P. Investigation of Mycobacterium ulcerans glycan interactions using glycan array and surface plasmon resonance. In: Pluschke G,Röltgen K, eds. Mycobacterium ulcerans:, 29-40. New York, NY: Humana, 2022. (Methods in molecular biology: 2387). DOI: 10.1007/978-1-0716-1779-3_4

2022
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Eddyani M, Affolabi D, Ablordey A, Eyangoh S, Pluschke G. Laboratory investigations in Buruli ulcer. In: Nunzi E,Massone C,Portaels F, eds. Leprosy and Buruli ulcer: a practical guide, 443-454. Cham: Springer Nature, 2022. DOI: 10.1007/978-3-030-89704-8_41

2022
Book Section

Fernandes B, Sousa M, Castro R, Schäfer A, Hauser J, Schulze K, Amacker M, Tamborrini M, Pluschke G, Alves P.M, Fleury S, Roldão A. Scalable process for high-yield production of PfCyRPA using insect cells for inclusion in a malaria virosome-based vaccine candidate. Front Bioeng Biotechnol. 2022;10:879078. DOI: 10.3389/fbioe.2022.87907

2022
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Hall B.S, Dos Santos S.J, Hsieh L.T, Manifava M, Ruf M.T, Pluschke G, Ktistakis N, Simmonds R.E. Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity. Autophagy. 2022;18(4):841-859. DOI: 10.1080/15548627.2021.1961067

2022
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Hsieh L.T, Dos Santos S.J, Hall B.S, Ogbechi J, Loglo A.D, Salguero F.J, Ruf M.T, Pluschke G, Simmonds R.E. Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions. PLoS Pathog. 2022;18:e1010280. DOI: 10.1371/journal.ppat.1010280

2022
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Leuenberger A, Koné B.V, N'krumah R.T.A.S, Koffi D.Y, Bonfoh B, Utzinger J, Pluschke G. Perceived water-related risk factors of Buruli ulcer in two villages of south-central Côte d’Ivoire. PLoS Negl Trop Dis. 2022;16(12):e0010927. DOI: 10.1371/journal.pntd.0010927

2022
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Muri L, Schubart A, Thorburn C, Zamurovic N, Holbro T, Kammüller M, Pluschke G, Ispasanie E. Inhibition of the different complement pathways has varying impacts on the serum bactericidal activity and opsonophagocytosis against Haemophilus influenzae type b. Front Immunol. 2022;13:1020580. DOI: 10.3389/fimmu.2022.1020580

2022
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Pluschke G,Röltgen K, eds. Mycobacterium ulcerans: methods and protocols. New York, NY: Humana Press, 2022. DOI: 10.1007/978-1-0716-1779-3

2022
Edited Book

Pluschke G, Röltgen K. Overview: development of drugs against Mycobacterium ulcerans. In: Pluschke G,Röltgen K, eds. Mycobacterium ulcerans:, 185-187. New York, NY: Humana, 2022. (Methods in molecular biology: 2387). DOI: 10.1007/978-1-0716-1779-3_17

2022
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Pluschke G, Röltgen K. Preface. In: Pluschke G,Röltgen K, eds. Mycobacterium ulcerans:, V-VI. New York, NY: Humana, 2022. DOI: 10.1007/978-1-0716-1779-3_1

2022
Book Section

Portaels F, Pluschke G. History and geographic distribution of Buruli ulcer. In: Nunzi E,Massone C,Portaels F, eds. Leprosy and Buruli ulcer: a practical guide, 421-430. Cham: Springer Nature, 2022. DOI: 10.1007/978-3-030-89704-8_39

2022
Book Section

Röltgen K, Johnson P.D.R, Pluschke G. Epidemiology of Buruli ulcer. In: Nunzi E,Massone C,Portaels F, eds. Leprosy and Buruli ulcer. A practical guide, 541-550. Cham: Springer Nature, 2022. DOI: 10.1007/978-3-030-89704-8_47

2022
Book Section

Röltgen K, Pluschke G. Overview: Mycobacterium ulcerans disease (Buruli ulcer). In: Pluschke G,Röltgen K, eds. Mycobacterium ulcerans:, 3-6. New York, NY: Humana, 2022. (Methods in molecular biology: 2387). DOI: 10.1007/978-1-0716-1779-3_1

2022
Book Section
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Röltgen K, Pluschke G. Overview: mycolactone, the macrolide toxin of Mycobacterium ulcerans. In: Pluschke G,Röltgen K, eds. Mycobacterium ulcerans:, 105-108. New York, NY: Humana, 2022. (Methods in molecular biology: 2387). DOI: 10.1007/978-1-0716-1779-3_11

2022
Book Section
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Toppino S, Koffi D.Y, Koné B.V, N'Krumah R.T.A.S, Coulibaly I.D, Tobian F, Pluschke G, Stojkovic M, Bonfoh B, Junghanss T. Community-based wound management in a rural setting of Côte d'Ivoire. PLoS Negl Trop Dis. 2022;16(10):e0010730. DOI: 10.1371/journal.pntd.0010730

2022
Journal Article
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Toppino S, N'Krumah R.T.A.S, Koné B.V, Koffi D.Y, Coulibaly I.D, Tobian F, Pluschke G, Stojkovic M, Bonfoh B, Junghanss T. Skin wounds in a rural setting of Côte d'Ivoire: population-based assessment of the burden and clinical epidemiology. PLoS Negl Trop Dis. 2022;16(10):e0010608. DOI: 10.1371/journal.pntd.0010608

2022
Journal Article
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Warryn L, Pluschke G. Efficacy of an acid-oxidising solution against Mycobacterium ulcerans. Antimicrob Agents Chemother. 2022;66(1):e00870-21. DOI: 10.1128/AAC.00870-21

2022
Journal Article
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Brunetti G, Padovani F, De Pastina A, Rotella C, Monahan Am, Hoffman S.L, Jongo S.A, Abdulla S, Corradin G, Pluschke G, Daubenberger C, Hegner M. Nanotechnological immunoassay for rapid label-free analysis of candidate malaria vaccines. Nanoscale. 2021;13(4):2338-2349. DOI: 10.1039/D0NR08083G

2021
Journal Article
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Day C.J, Röltgen K, Pluschke G, Jennings M.P. The cell surface protein MUL_3720 confers binding of the skin pathogen Mycobacterium ulcerans to sulfated glycans and keratin. PLoS Negl Trop Dis. 2021;15(2):e0009136. DOI: 10.1371/journal.pntd.0009136

2021
Journal Article
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Ispasanie E, Muri L, Schubart A, Thorburn C, Zamurovic N, Holbro T, Kammüller M, Pluschke G. Alternative complement pathway inhibition does not abrogate meningococcal killing by serum of vaccinated individuals. Front Immunol. 2021;12:747594. DOI: 10.3389/fimmu.2021.747594

2021
Journal Article
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Please H.R, Vas Nunes J.H, Patel R, Pluschke G, Tholley M, Ruf M.T, Bolton W, Scott J.A, Grobusch M.P, Bolkan H.A, Brown J.M, Jayne D.G. Chronic wounds in Sierra Leone: searching for Buruli ulcer, a NTD caused by Mycobacterium ulcerans, at Masanga Hospital. PLoS Negl Trop Dis. 2021;15(10):e0009862. DOI: 10.1371/journal.pntd.0009862

2021
Journal Article
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Warryn L, Dangy J.P, Gersbach P, Gehringer M, Altmann K.H, Pluschke G. An antigen capture assay for the detection of mycolactone, the polyketide toxin of Mycobacterium ulcerans. J Immunol. 2021;206(11):2753-2762. DOI: 10.4049/jimmunol.2001232

2021
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Borel N, Sauer-Durand A.M, Hartel M, Kuratli J, Vaupel P, Scherr N, Pluschke G. wIRA: hyperthermia as a treatment option for intracellular bacteria, with special focus on Chlamydiae and Mycobacteria. Int J Hyperthermia. 2020;37:373-383. DOI: 10.1080/02656736.2020.1751312

2020
Journal Article
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Chaguza C, Yang M, Cornick J.E, du Plessis M, Gladstone R.A, Kwambana-Adams B.A, Lo S.W, Ebruke C, Tonkin-Hill G, Peno C, Senghore M, Obaro S.K, Ousmane S, Pluschke G, Collard J.M, Sigaùque B, French N, Klugman K.P, Heyderman R.S, McGee L, Antonio M, Breiman R.F, von Gottberg A, Everett D.B, Kadioglu A, Bentley S.D. Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism. Commun Biol. 2020;3:559. DOI: 10.1038/s42003-020-01290-9

2020
Journal Article
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Röltgen K, Pluschke G, Spencer J.S, Brennan P.J, Avanzi C. The immunology of other mycobacteria: M. ulcerans, M. leprae. Semin Immunopathol. 2020;42(3):333-353. DOI: 10.1007/s00281-020-00790-4

2020
Journal Article
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Röltgen K, Pluschke G. Buruli ulcer: the efficacy of innate immune defense may be a key determinant for the outcome of infection with Mycobacterium ulcerans. Front Microbiol. 2020;11:1018. DOI: 10.3389/fmicb.2020.01018

2020
Journal Article
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Tamborrini M, Hauser J, Schäfer A, Amacker M, Favuzza P, Kyungtak K, Fleury S, Pluschke G. Vaccination with virosomally formulated recombinant CyRPA elicits protective antibodies against Plasmodium falciparum parasites in preclinical in vitro and in vivo models. Vaccines. 2020;5:9. DOI: 10.1038/s41541-020-0158-9

2020
Journal Article
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Thomas S.S, Kalia N.P, Ruf M.T, Pluschke G, Pethe K. Toward a single-dose cure for Buruli ulcer. Antimicrob Agents Chemother. 2020;64(9):e00727-20. DOI: 10.1128/AAC.00727-20

2020
Journal Article
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Vandelannoote K, Pluschke G, Bolz M, Bratschi M.W, Kerber S, Stinear T.P, de Jong B.C. Introduction of Mycobacterium ulcerans disease in the Bankim Health District of Cameroon follows damming of the Mapé river. PLoS Negl Trop Dis. 2020;14(9):e0008501. DOI: 10.1371/journal.pntd.0008501

2020
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Warryn L, Dangy J.P, Gersbach P, Gehringer M, Schäfer A, Ruf M.T, Ruggli N, Altmann K.H, Pluschke G. Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans. PLoS Negl Trop Dis. 2020;14(6):e0008357. DOI: 10.1371/journal.pntd.0008357

2020
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Gehringer M, Mäder P, Gersbach P, Pfeiffer B, Scherr N, Dangy J.P, Pluschke G, Altmann K.H. Configurationally stabilized analogs of M. ulcerans exotoxins mycolactones A and B reveal the importance of side chain geometry for mycolactone virulence. Org Lett. 2019;21(15):5853-5857. DOI: 10.1021/acs.orglett.9b01947

2019
Journal Article
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Guenin-Macé L, Ruf M.T, Pluschke G, Demangel C. Mycolactone: more than just a cytotoxin. In: Pluschke G,Röltgen K, eds. Buruli ulcer: , 117-134. Cham: Springer, 2019. DOI: 10.1007/978-3-030-11114-4_7

2019
Book Section

Piazena H, Müller W, Pendl W, von Ah S, Cap V.H, Hug P.J, Sidler X, Pluschke G, Vaupel P. Thermal field formation during wIRA-hyperthermia: temperature measurements in skin and subcutis of piglets as a basis for thermotherapy of superficial tumors and local skin infections caused by thermosensitive microbial pathogens. Int J Hyperthermia. 2019;36(1):938-952. DOI: 10.1080/02656736.2019.1655594

2019
Journal Article
PubMed