Baert L, Rudy S, Pellisson M, Doll T, Rocchetti R, Kaiser M, Mäser P, Müller M. Induced pluripotent stem cell-derived human macrophages as an infection model for Leishmania donovani. PLoS Negl Trop Dis. 2024;18(1):e001155. DOI: 10.1371/journal.pntd.0011559

2024
Journal Article
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Hamid A, Mäser P, Mahmoud A.B. Drug repurposing in the chemotherapy of infectious diseases. Molecules. 2024;29(3):635. DOI: 10.3390/molecules29030635

2024
Journal Article
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Seebacher W, Hoffelner M, Belaj F, Kaiser M, Mäser P, Saf R, Pferschy-Wenzig E.M, Weis R. Tetrahydropyridinylidene ammonium salts with arylalkyl and diarylalkyl substitution and their antiprotozoal activity. Monatsh Chem. 2024;155:73-81. DOI: 10.1007/s00706-023-03142-8

2024
Journal Article

Walesch S, Garcia R, Mahmoud A.B, Panter F, Bollenbach S, Mäser P, Kaiser M, Krug D, Müller R. New myxobacteria of the Myxococcaceae clade produce angiolams with antiparasitic activities. Microbiol Spectr. 2024(in press). DOI: 10.1128/spectrum.03689-23

2024
Journal Article
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Albisetti A, Hälg S, Zoltner M, Mäser P, Wiedemar N. Suramin action in African trypanosomes involves a RuvB-like DNA helicase. Int J Parasitol Drugs Drug Resist. 2023;23:44-53. DOI: 10.1016/j.ijpddr.2023.09.003

2023
Journal Article
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Burri C, Mäser P, Chappuis F. Human African trypanosomiasis. In: Farrar J,Hotez P.J,Junghanss T,Kang G,Lalloo D,White N.J,Garcia P.J, eds. Manson's Tropical Diseases, 623-635. Amsterdam: Elsevier, 2023. DOI: 10.1016/B978-0-7020-7959-7.00051-8

2023
Book Section

Fesser A, Beilstein S, Kaiser M, Schmidt R.S, Mäser P. Trypanosoma cruzi STIB980: a TcI strain for drug discovery and reverse genetics. Pathogens. 2023;12(10):1217. DOI: 10.3390/pathogens12101217

2023
Journal Article
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Hinteregger C, Dolensky J, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R. Synthesis and antiprotozoal activity of azabicyclo-nonane pyrimidine hybrids. Molecules. 2023;28:307. DOI: 10.3390/molecules28010307

2023
Journal Article
PubMed

Hochegger P, Hermann T, Dolensky J, Seebacher W, Saf R, Pferschy-Wenzig E.M, Kaiser M, Mäser P, Weis R. Structure-activity relationships and antiplasmodial potencies of novel 3,4-disubstituted 1,2,5-oxadiazoles. Int J Mol Sci. 2023;24(19):14480. DOI: 10.3390/ijms241914480

2023
Journal Article
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Mäser P, Bernhard S, Brun R, Burri C, Gagneux S, Hetzel M.W, Kaiser M, Lengeler C, Pluschke G, Reus E, Rottmann M, Utzinger J, Warryn L, Wittlin S, Keiser J. Key contributions by the Swiss Tropical and Public Health Institute towards new and better drugs for tropical diseases. Chimia (Aarau). 2023;77(9):593-606. DOI: 10.2533/chimia.2023.593

2023
Journal Article
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Meier L, Antillón M, Burri C, Chitnis N, Endriss Y, Keiser J, Moore S, Müller P, Penny M, Voss T.S, Mäser P, Utzinger J. Repurposing know-how for drug development: case studies from the Swiss Tropical and Public Health Institute. Chimia (Aarau). 2023;77(9):582-592. DOI: 10.2533/chimia.2023.582

2023
Journal Article
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Rao S.P.S, Gould M.K, Noeske J, Saldivia M, Jumani R.S, Ng P.S, Rene O, Chen Y.L, Kaiser M, Ritchie R, Francisco A.F, Johnson N, Patra D, Cheung H, Deniston C, Schenk A.D, Cortopassi W.A, Schmidt R.S, Wiedemar N, Thomas B, Palkar R, Ghafar N.A, Manoharan V, Luu C, Gable J.E, Wan K.F, Myburgh E, Mottram J.C, Barnes W, Walker J, Wartchow C, Aziz N, Osborne C, Wagner J, Sarko C, Kelly J.M, Manjunatha U.H, Mäser P, Jiricek J, Lakshminarayana S.B, Barrett M.P, Diagana T.T. Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science. 2023;380(6652):1349-1356. DOI: 10.1126/science.adh0614

2023
Journal Article
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Seebacher W, Kaiser M, Mäser P, Saf R, Pferschy-Wenzig E.M, Weis R. Benzyl- and dibenzyl tetrahydropyridinylidene ammonium salts with antiplasmodial and antitrypanosomal activity. Monatsh Chem. 2023;154:105-114. DOI: 10.1007/s00706-022-03003-w

2023
Journal Article

Sevik Kilicaslan O, Cretton S, Hausmann E, Quirós-Guerrero L, Karimou S, Kaiser M, Mäser P, Christen P, Cuendet M. Antiprotozoal activity of natural products from Nigerien plants used in folk medicine. Front Pharmacol. 2023;14:1190241. DOI: 10.3389/fphar.2023.1190241

2023
Journal Article
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Utzinger J, Mäser P. Editorial: Swiss TPH: 30 Years of R&D towards new drugs for tropical diseases. Chimia (Aarau). 2023;77(9):570-571. DOI: 10.2533/chimia.2023.570

2023
Journal Item
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Utzinger J,Mäser P, eds. Swiss TPH: 30 years of R&D towards new drugs for tropical diseases. 77. Special issue, 2023. DOI: 10.2533/chimia.2023.570

2023
Edited Book

Walz A, Duffey M, Aljayyoussi G, Sax S, Leroy D, Besson A, Burrows J.N, Cherkaoui-Rbati M.H, Gobeau N, Westwood M-A, Siethoff C, Gamo S, Mäser P, Wittlin S. The Parasite Reduction Ratio (PRR) assay version 2: standardized assessment of Plasmodium falciparum viability after antimalarial treatment in vitro. Pharmaceuticals (Basel). 2023;16(2):163. DOI: 10.3390/ph16020163

2023
Journal Article
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Beilstein S, El Phil R, Sahraoui S.S, Scapozza L, Kaiser M, Mäser P. Laboratory selection of trypanosomatid pathogens for drug resistance. Pharmaceuticals (Basel). 2022;15(2):135. DOI: 10.3390/ph15020135

2022
Journal Article
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Bernhard S, Kaiser M, Burri C, Mäser P. Fexinidazole for human African trypanosomiasis, the fruit of a successful public-private partnership. Diseases. 2022;10(4):90. DOI: 10.3390/diseases10040090

2022
Journal Article
PubMed

Dolensky J, Hinteregger C, Leitner A, Seebacher W, Saf R, Belaj F, Mäser P, Kaiser M, Weis R. Antiprotozoal activity of azabicyclo-nonanes linked to tetrazole or sulfonamide cores. Molecules. 2022;27(19):6217. DOI: 10.3390/molecules27196217

2022
Journal Article
PubMed

Hermann T, Wallner R, Dolensky J, Seebacher W, Pferschy-Wenzig E.-M, Kaiser M, Mäser P, Weis R. New derivatives of the multi-stage active Malaria Box compound MMV030666 and their antiplasmodial potencies. Pharmaceuticals (Basel). 2022;15(12):1503. DOI: 10.3390/ph15121503

2022
Journal Article

Koester D.C, Marx V.M, Williams S, Jiricek J, Dauphinais M, René O, Miller S.L, Zhang L, Patra D, Chen Y.L, Cheung H, Gable J, Lakshminarayana S.B, Osborne C, Galarneau J.R, Kulkarni U, Richmond W, Bretz A, Xiao L, Supek F, Wiesmann C, Honnappa S, Be C, Mäser P, Kaiser M, Ritchie R, Barrett M.P, Diagana T.T, Sarko C, Rao S.P.S. Discovery of novel quinoline-based proteasome inhibitors for human African trypanosomiasis (HAT). J Med Chem. 2022;65:11776−11787. DOI: 10.1021/acs.jmedchem.2c00791

2022
Journal Article
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Mäser P. Filariae as organisms. In: Kaminsky R,Geary T,Selter P, eds. Human and animal filariases: landscape, challenges, and control, 17-32: Wiley, 2022

2022
Book Section

Mousavi A, Foroumadi P, Emamgholipour Z, Mäser P, Kaiser M, Foroumadi A. 2-(Nitroaryl)-5-substituted-1,3,4-thiadiazole derivatives with antiprotozoal activities: in vitro and in vivo study. Molecules. 2022;27:5559. DOI: 10.3390/molecules27175559

2022
Journal Article
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Scheiber N, Blaser G, Pferschy-Wenzig E.M, Kaiser M, Mäser P, Presser A. Efficient oxidative dearomatisations of substituted phenols using hypervalent iodine (iii) reagents and antiprotozoal evaluation of the resulting cyclohexadienones against T. b. rhodesiense and P. falciparum strain NF54. Molecules. 2022;27(19):6559. DOI: 10.3390/molecules27196559

2022
Journal Article
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Sevik Kilicaslan O, Cretton S, Quiros-Guerrero L, Bella M.A, Kaiser M, Mäser P, Ndongo J.T, Cuendet M. Isolation and structural elucidation of compounds from Pleiocarpa bicarpellata and their in vitro antiprotozoal activity. Molecules. 2022;27(7):2200. DOI: 10.3390/molecules27072200

2022
Journal Article
PubMed

Barth-Jaeggi T, Mäser P. Leishmaniasis in Europe and Central Asia: epidemiology, impact of habitat and lifestyle changes, HIV coinfection. In: Steinmann P,Utzinger J, eds. Neglected tropical diseases - Europe and Central Asia, 83-100. Cham: Springer, 2021. DOI: 10.1007/978-3-030-84224-6_5

2021
Book Section

Boberg M, Cal M, Kaiser M, Jansson-Lofmark R, Mäser P, Ashton M. Enantiospecific antitrypanosomal in vitro activity of eflornithine. PLoS Negl Trop Dis. 2021;15(7):e0009583. DOI: 10.1371/journal.pntd.0009583

2021
Journal Article
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Brand M, Wang L, Agnello S, Gazzola S, Gall F.M, Raguz L, Kaiser M, Schmidt R.S, Ritschl A, Jelk J, Hemphill A, Mäser P, Butikofer P, Adams M, Riedl R. Antiprotozoal structure-activity relationships of synthetic leucinostatin derivatives and elucidation of their mode of action. Angew Chem Int Ed Engl. 2021;60(28):15613-15621. DOI: 10.1002/anie.202102153

2021
Journal Article
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Cretton S, Genta-Jouve G, Kaiser M, Mäser P, Muñoz O, Bürgi T, Cuendet M, Christen P. Hygroline derivatives from Schizanthus tricolor and their anti-trypanosomatid and antiplasmodial activities. Phytochemistry. 2021;192:112957. DOI: 10.1016/j.phytochem.2021.112957

2021
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Fesser A, Kaiser M, Mäser P. Neue Parameter für die Wirkstofftestung gegen Trypanosoma cruzi. Biospektrum (Heidelb). 2021;27(2):168-170. DOI: 10.1007/s12268-021-1554-z

2021
Journal Article
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Flittner D, Kaiser M, Mäser P, Lopes N.P, Schmidt T.J. The alkaloid-enriched fraction of Pachysandra terminalis (Buxaceae) shows prominent activity against Trypanosoma brucei rhodesiense. Molecules. 2021;26(3):591. DOI: 10.3390/molecules26030591

2021
Journal Article
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Greve H.L, Kaiser M, Mäser P, Schmidt T.J. Boswellic acids show in vitro activity against Leishmania donovani. Molecules. 2021;26(12):3651. DOI: 10.3390/molecules26123651

2021
Journal Article
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Hermann T, Hochegger P, Dolensky J, Seebacher W, Pferschy-Wenzig E.M, Saf R, Kaiser M, Mäser P, Weis R. Synthesis and structure-activity relationships of new 2-phenoxybenzamides with antiplasmodial activity. Pharmaceuticals (Basel). 2021;14:1109. DOI: 10.3390/ph14111109

2021
Journal Article
PubMed

Hermann T, Hochegger P, Dolensky J, Seebacher W, Saf R, Kaiser M, Mäser P, Weis R. New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities. Pharmaceuticals (Basel). 2021;14(5):412. DOI: 10.3390/ph14050412

2021
Journal Article
PubMed

Hitz E, Wiedemar N, Passecker A, Graça B.A.S, Scheurer C, Wittlin S, Brancucci N.M.B, Vakonakis I, Mäser P, Voss T.S. The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites. PLoS Biol. 2021;19(12):e3001483. DOI: 10.1371/journal.pbio.3001483

2021
Journal Article
PubMed

Hochegger P, Dolensky J, Seebacher W, Saf R, Kaiser M, Mäser P, Weis R. 8-amino-6-methoxyquinoline-tetrazole hybrids: Impact of linkers on antiplasmodial activity. Molecules. 2021;26(18):5530. DOI: 10.3390/molecules26185530

2021
Journal Article
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Hoffelner M.H, Seebacher W, Kaiser M, Mäser P, Pferschy-Wenzig E.M, Saf R, Belaj F, Kretschmer N, Alajlani M, Brantner A, Bauer R, Weis R. Unexpected ring‑opening of 2,3‑dihydropyridines. Monatsh Chem. 2021;152:1347–1359. DOI: 10.1007/s00706-021-02847-y

2021
Journal Article

Llurba Montesino N, Kaiser M, Mäser P, Schmidt T.J. Nucleic acid amplification techniques for the detection of Schistosoma mansoni infection in humans and the intermediate snail host: a structured review and meta-analysis of diagnostic accuracy. Molecules. 2021;26(11):3226. DOI: 10.3390/molecules26113226

2021
Journal Article
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Mahmoud A.B, Abd Algaffar S, van de Sande W, Khalid S, Kaiser M, Mäser P. Niclosamide is active in vitro against mycetoma pathogens. Molecules. 2021;26(13):4005. DOI: 10.3390/molecules26134005

2021
Journal Article
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