Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents (Publications)
We report herein the synthesis and trypanocidal profile of new (E)-cinnamic N-acylhydrazones (NAHs) designed by exploiting molecular hybridization between the potent cruzain inhibitors (E)-1-(benzo[d]
The global burden of disease due to outdoor air pollution (Publications)
As part of the World Health Organization (WHO) Global Burden of Disease Comparative Risk Assessment, the burden of disease attributable to urban ambient air pollution was estimated in terms of deaths
Manadoperoxides, a new class of potent antitrypanosomal agents of marine origin (Publications)
Chemical investigation of the marine sponge Plakortis cfr. lita afforded a library of endoperoxyketal polyketides, manadoperoxides B-K (3-5 and 7-13) and peroxyplakoric esters B(3) (6) and C (14). Eig
Pharmacotherapy, vaccines and malaria advice for HIV-infected travellers (Publications)
Since the introduction of effective antiretroviral therapy (ART), HIV-infected individuals are travelling more frequently and international travel has become much safer. Specific concerns include the
The influence of sensitisation to pollens and moulds on seasonal variations in asthma attacks (Publications)
No large study has described seasonal variation in asthma attacks in population based asthmatics in whom sensitisation to allergen has been measured.2,637 young adults with asthma living in 15 countri
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria (Publications)
Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase I clinical trials, where it was shown to
Bone response to loaded implants with non-matching implant-abutment diameters in the canine mandible (Publications)
Background: One way to evaluate various implant restorations is to measure the amount of bone change that occurs at the crestal bone. The objective of this study was to histologically evaluate the alv