Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS) (Publications)
BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially mod
A role for systems epidemiology in tuberculosis research (Publications)
Despite being a curable disease, tuberculosis (TB) killed more people in 2009 than during any previous year in history. Progress in TB research has been slow, and remains burdened by important gaps in
Antiparasitic activity of marine pyridoacridone alkaloids related to the ascididemins (Publications)
A series of pyridoacridone alkaloids, including the marine alkaloid ascididemin were tested in vitro for antiparasitic activity against P. falciparum (K1, NF54), L. donovani, T. cruzi, T. b. rhodesien
Influence of HIV-related immunodeficiency on the risk of hepatocellular carcinoma (Publications)
OBJECTIVE: To investigate HIV-related immunodeficiency as a risk factor for hepatocellular carcinoma (HCC) among persons infected with HIV, while controlling for the effect of frequent coinfection wit
Honeys from different floral sources as inhibitors of enzymatic browning in fruit and vegetable homogenates (Publications)
Honeys from different floral sources were evaluated for their antioxidant content and for their ability to inhibit enzymatic browning in fruits and vegetables. Antioxidant contents of honeys vary wide
Incidence of asthma and net change in symptoms in relation to changes in obesity (Publications)
The incidence of asthma has been reported to be associated with obesity. An alternative analysis, of net change in prevalence, does not require exclusion of those with asthma at baseline.Follow-up dat
Oral treatment for <em>Mycobacterium ulcerans</em> infection: results from a pilot study in Benin (Publications)
Mycobacterium ulcerans infection is responsible for severe skin lesions in sub-Saharan Africa. We enrolled 30 Beninese patients with Buruli ulcers in a pilot study to evaluate efficacy of an oral chem
Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase (Publications)
Novel quinazoline-type compounds were designed as inhibitors of the parasite specific enzyme trypanothione reductase (TR), and their biological activities were evaluated. Some of our compounds inhibit
Cost-effectiveness of invasive versus medical management of elderly patients with chronic symptomatic coronary artery disease. Findings of the... (Publications)
AIM: To compare benefits and costs of invasive versus medical management in elderly patients with chronic angina. METHODS AND RESULTS: In a predefined subgroup of 188 patients of the Trial of Invasive