Conjugation of quinones with natural polyamines: towards an expanded anti-trypanosomatid profile (Publications)
A combinatorial library of quinone-polyamine conjugates designed to optimize the anti-trypanosomatid profile of hit compounds 1 and 2 has been prepared by a solid phase approach. The conjugates were e
Glutathione transferase (GSTM1) null genotype, smoking, and prevalence of colorectal adenomas (Publications)
Colorectal cancer is caused by environmental exposures and genetic predisposition. However, little is known of hereditary factors that influence development of common, non-Mendelian forms of this canc
Alcohol and smoking in relation to the prevalence of adenomatous colorectal polyps detected at sigmoidoscopy (Publications)
Cigarette smoking has been associated with adenomatous polyps of the large bowel but not with increased risk of colorectal cancer. Giovannucci et al recently proposed a hypothesis to explain this inco
Health in the urban environment: experience from Dar es Salaam/Tanzania (Publications)
Dar es Salaam is a typical example of the rapid urbanization process in sub-Saharan Africa. Health problems in the city are tremendous and reflect the epidemiologic transition, with the emergence of c