MATIAS (Page)
https://www.swisstph.ch/fr/about/med/medicines-implementation-research/matias
for treatment of severe malaria caused by Plasmodium falciparum . These results with high quality evidence led to a change in the WHO guidelines for the treatment of severe malaria in children and adults [...] Key Project | MATIAS Treatment of Severe Malaria with Injectable Artesunate Implementation Non-Controlled Longitudinal Observational Study to Support Artesunate Introduction in the Democratic Republic [...] the Congo (DRC) In 2010, the AQUAMAT study demonstrated that, in children, the...
Clinical Immunology (Page)
https://www.swisstph.ch/fr/about/mpi/clinical-immunology
Nele von Planta Selected Projects EGMVI - Equatorial Guinea Malaria Vaccine Initiative MAL067 - MAL067 - Studies towards understanding RTS,S malaria vaccine induced protection SNF_FP_modelling - Multi-scale [...] development of novel drugs against malaria. Lancet Infect Dis . 2022;22:753-754. DOI: 10.1016/S1473-3099(21)00679-4 Daubenberger C. Assessment of experimental malaria vaccine induced protection in pre-exposed [...] well as host factors elicited by subunit and whole parasite vaccines...
Vaccine potentials of an intrinsically unstructured fragment derived from the blood stage-associated <em>Plasmodium falciparum</em> protein PFF0165c (Publications)
with its low polymorphism and association with clinical protection from malaria in humans, warrant its further development as a malaria vaccine candidate [...] We have identified new malaria vaccine candidates through the combination of bioinformatics prediction of stable protein domains in the Plasmodium falciparum genome, chemical synthesis of polypeptides [...] assays, and association of an antigen-specific antibody response with protection against clinical malaria. Within the predicted open...
Medicines Implementation Research | Research at Swiss TPH (Page)
https://www.swisstph.ch/fr/about/med/miru
Treatment of severe Malaria The serious disease malaria is a major burden in tropical and subtropical countries. Although great efforts have been made to control and eliminate malaria, more than 400,000 [...] Rectal Artesunate for Malaria Many children suffering from severe malaria live in poor rural communities with no access to health care. Where parenteral treatment of severe malaria is not available, the [...] Artesunate to Treat Severe Malaria The serious disease malaria is a high burden in...
Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased... (Publications)
shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could [...] could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination. METHODS: Using a standardized enzyme-linked immunosorbent assay, IgG antibodies [...] were associated with differential protection against naturally transmitted Pf...
Reduction in the proportion of fevers associated with <em>Plasmodium falciparum</em> parasitaemia in Africa: a systematic review (Publications)
BACKGROUND: Malaria is almost invariably ranked as the leading cause of morbidity and mortality in Africa. There is growing evidence of a decline in malaria transmission, morbidity and mortality over the [...] presenting with a syndrome of 'presumptive malaria', 3) numerators (number of parasitologically confirmed cases) and denominators (total number of presumptive malaria cases) available, 4) good quality microscopy [...] However, there is still doubt whether this decline is reflected in a...
Use of insecticides in agriculture and the prevention of vector-borne diseases: population knowledge, attitudes, practices and beliefs in Elibou,... (Publications)
and beliefs (KAPB) pertaining to malaria are generally well described. However, little is known about population knowledge and awareness of insecticide resistance in malaria vectors. The aim of this study [...] resistance in malaria vectors, while people's knowledge about insecticide resistance was limited. There is a need to raise awareness in communities about the presence of resistance in malaria vectors and [...] study was to investigate KAPB related to insecticide resistance in malaria...
The empirical support for the radical cure strategy for eliminating <em>Plasmodium vivax</em> in China (Publications)
China is malaria-free, it is timely to consider how elimination of malaria was completed in People's Republic of China over the last 7 decades. Of the four widespread species of human malaria, Plasmodium [...] planning disease elimination in other malaria-endemic countries, with residual P. vivax malaria. METHODS: We collated data from both published and unpublished malaria parasite inoculation experiments conducted [...] (late spring) seasons had a pronounced effect on outbreaks during the mala...
The risk of malarial infections and disease in Papua New Guinean children (Publications)
vivax = 5.28), they were 21 times more likely to develop symptomatic P. falciparum malaria (1.17/year) than P. vivax malaria (0.06/year). Children greater than nine years of age had a reduced risk of acquiring [...] to symptomatic P. falciparum malaria remained incomplete. These observations suggest that different mechanisms of immunity may be important for protection from these malaria species [...] study of 206 Papua New Guinean school children, we examined risk of reinfection and symptomatic ...
Heterogeneity in P<em>lasmodium falciparum </em>whole sporozoite vaccine induced humoral immune responses and protection in African volunteers: the... (Publications)
geographical overlap of HIV and malaria, an effective malaria vaccine deployed in this population could possibly support the long-term objective of regional elimination of malaria by using mass vaccination. [...] and 405,000 deaths attributed to malaria. New tools such as efficacious vaccines, better drugs and diagnostics are needed to supplement the current malaria control tools that rest mainly on vector control [...] against malaria induced by these whole sporozoite based vaccines varies...